MDC1 and SMC1A

Number of citations of the paper that reports this interaction (PMID 12607005)
193

Data Source:
HPRD (in vivo)

		MDC1	SMC1A
Gene Name		mediator of DNA-damage checkpoint 1	structural maintenance of chromosomes 1A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Cohesin Core Heterodimer Meiotic Cohesin Complex
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Intra-S DNA Damage Checkpoint	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle MRNA Splicing, Via Spliceosome DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division RNA Splicing Response To Radiation Gene Expression Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Signal Transduction In Response To DNA Damage Cell Division
Pathways		ATM mediated phosphorylation of repair proteins ATM mediated response to DNA double-strand break Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Establishment of Sister Chromatid Cohesion Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin mRNA Splicing - Major Pathway Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251	16 interactors: ATM BLM BRCA1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3
Entrez ID		9656	8243
HPRD ID		16252	02077
Ensembl ID		ENSG00000137337	ENSG00000072501
Uniprot IDs		A1Z5I9 Q14676	Q14683 Q68EN4
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cell Cycle Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process Response To Ionizing Radiation Positive Regulation Of Metabolic Process Chromosome Organization Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Response To Radiation Regulation Of Metabolic Process DNA Recombination Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Abiotic Stimulus Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Protein Modification Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Cell Cycle Process Cell Cycle Mitotic Cell Cycle DNA Recombination Mitotic Cell Cycle Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Double-strand Break Repair Organelle Organization Cellular Response To Stress Meiotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Chromosome Organization DNA Strand Elongation DNA-dependent DNA Replication DNA Replication DNA Damage Checkpoint Meiotic Nuclear Division Telomere Maintenance Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Meiosis I DNA Replication Initiation Response To Stress Meiotic Mismatch Repair Nitrogen Compound Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Reciprocal Meiotic Recombination Mitotic Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway Response To Radiation Regulation Of DNA Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation DNA Duplex Unwinding DNA Geometric Change
Tagcloud ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected
Tagcloud (Difference) ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected
Tagcloud (Intersection) ?