SMC1A and MET

Number of citations of the paper that reports this interaction (PMID 15546961)
3

Data Source:
HPRD (two hybrid)

		SMC1A	MET
Gene Name		structural maintenance of chromosomes 1A	MET proto-oncogene, receptor tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Cohesin Core Heterodimer Meiotic Cohesin Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Phosphatase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle MRNA Splicing, Via Spliceosome DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division RNA Splicing Response To Radiation Gene Expression Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Signal Transduction In Response To DNA Damage Cell Division	Activation Of MAPK Activity Endothelial Cell Morphogenesis Liver Development Placenta Development Signal Transduction Cell Surface Receptor Signaling Pathway Axon Guidance Brain Development Skeletal Muscle Tissue Development Cell Proliferation Positive Regulation Of Glucose Transport Muscle Cell Migration Myotube Differentiation Peptidyl-tyrosine Phosphorylation Adult Behavior Glucose Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Myoblast Proliferation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Establishment of Sister Chromatid Cohesion Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin mRNA Splicing - Major Pathway Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase	Axon guidance Semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling
Drugs			K-252a 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Cabozantinib
Diseases
GWAS			Multiple sclerosis (severity) ( 19010793)
Protein-Protein Interactions		16 interactors: ATM BLM BRCA1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3	37 interactors: BAG1 CASP3 CBL CNR1 CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR FAS GAB1 GLMN GRB2 HGF HGS INPP5D INPPL1 ITGB4 MUC20 PCBD2 PIK3R1 PLCG1 PLXNB1 PTPN11 PTPRB PTPRJ RANBP10 RANBP9 SHC1 SMC1A SNAPIN SNX2 SPSB1 SRC STAT3 VAV1
Entrez ID		8243	4233
HPRD ID		02077	01280
Ensembl ID		ENSG00000072501	ENSG00000105976
Uniprot IDs		Q14683 Q68EN4	B4DLF5 P08581
PDB IDs			1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4K3J
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Cell Cycle Mitotic Cell Cycle DNA Recombination Mitotic Cell Cycle Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Double-strand Break Repair Organelle Organization Cellular Response To Stress Meiotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Chromosome Organization DNA Strand Elongation DNA-dependent DNA Replication DNA Replication DNA Damage Checkpoint Meiotic Nuclear Division Telomere Maintenance Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Meiosis I DNA Replication Initiation Response To Stress Meiotic Mismatch Repair Nitrogen Compound Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Reciprocal Meiotic Recombination Mitotic Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway Response To Radiation Regulation Of DNA Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation DNA Duplex Unwinding DNA Geometric Change	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Regulation Of Cell Activation Response To Growth Factor Developmental Process System Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Regulation Of Signal Transduction Multicellular Organismal Development Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Cell Communication Regulation Of Lymphocyte Activation Locomotion Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Phosphorylation Cell Differentiation Cell Motility Anatomical Structure Morphogenesis Neuron Differentiation Intracellular Signal Transduction Response To Organic Substance Neurogenesis Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Cell Migration Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Death Generation Of Neurons Regulation Of T Cell Activation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Response To Stimulus
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected	basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected	basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?