MDC1 and ZNF251

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		MDC1	ZNF251
Gene Name		mediator of DNA-damage checkpoint 1	zinc finger protein 251
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion	Nucleus
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Intra-S DNA Damage Checkpoint	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		ATM mediated phosphorylation of repair proteins ATM mediated response to DNA double-strand break Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251	5 interactors: FEZ1 FEZ2 MDC1 PAXIP1 SMAD1
Entrez ID		9656	90987
HPRD ID		16252	19696
Ensembl ID		ENSG00000137337	ENSG00000198169
Uniprot IDs		A1Z5I9 Q14676	Q9BRH9
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cell Cycle Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process Response To Ionizing Radiation Positive Regulation Of Metabolic Process Chromosome Organization Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Response To Radiation Regulation Of Metabolic Process DNA Recombination Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Abiotic Stimulus Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Protein Modification Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Regulation Of Dendrite Morphogenesis Regulation Of Dendrite Development Positive Regulation Of Histone H3-K36 Methylation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Projection Development DNA Recombination Connective Tissue Development Primary MiRNA Processing Positive Regulation Of Cell Projection Organization Locomotion Osteoblast Fate Commitment Chorion Development Cellular Response To Stimulus Positive Regulation Of Neuron Differentiation Cell Differentiation Intra-S DNA Damage Checkpoint Movement Of Cell Or Subcellular Component Regulation Of Neuron Projection Development SMAD Protein Complex Assembly Generation Of Neurons Axon Guidance Negative Regulation Of Macroautophagy Positive Regulation Of Neurogenesis Neurogenesis Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Mesodermal Cell Fate Commitment Positive Regulation Of Histone H3-K4 Methylation Establishment Of Mitochondrion Localization Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization System Development Cardiac Muscle Cell Proliferation Positive Regulation Of Cell Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Histone Acetylation Cellular Response To BMP Stimulus Regulation Of DNA-templated Transcription, Initiation Axonogenesis Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Regulation Of Neuron Differentiation Response To Stimulus Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Mesodermal Cell Differentiation Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta
Tagcloud (Difference) ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta
Tagcloud (Intersection) ?