MDC1 and ATM

Number of citations of the paper that reports this interaction (PMID 12607005)
193

Data Source:
HPRD (in vivo)

		MDC1	ATM
Gene Name		mediator of DNA-damage checkpoint 1	ATM serine/threonine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion	Chromosome, Telomeric Region Nucleoplasm Spindle Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Protein Complex Binding Histone Serine Kinase Activity Protein Dimerization Activity Protein N-terminus Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Intra-S DNA Damage Checkpoint	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion DNA Repair Double-strand Break Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Signal Transduction Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation V(D)J Recombination Cellular Response To Heat Histone-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Oocyte Development Neuron Apoptotic Process Histone MRNA Catabolic Process Cellular Response To Gamma Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Regulation Of Cellular Response To Heat
Pathways		ATM mediated phosphorylation of repair proteins ATM mediated response to DNA double-strand break Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Fanconi Anemia pathway G2/M Checkpoints Cellular Senescence p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Regulation of the Fanconi anemia pathway Stabilization of p53 p53-Independent DNA Damage Response Homologous recombination repair of replication-independent double-strand breaks p53-Independent G1/S DNA damage checkpoint Double-Strand Break Repair G1/S DNA Damage Checkpoints ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Meiotic recombination ATM mediated response to DNA double-strand break G2/M DNA damage checkpoint Regulation of HSF1-mediated heat shock response Cellular response to heat stress Autodegradation of the E3 ubiquitin ligase COP1 Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Melanoma ( 21983787) Response to metformin ( 21186350 21845381)
Protein-Protein Interactions		37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251	76 interactors: AATF ABL1 AP1B1 AP2A2 AP2B1 AP3B2 ATR BCL10 BLM BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 CREB1 CSNK1D CXXC5 DAXX DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EXO1 FANCD2 FOXO3 H2AFX HIF1A KAT5 KAT8 LIG4 MCM2 MDC1 MDM2 MDM4 MRE11A NBN PARP1 PEX5 POLR2A PRKDC PTS RAD17 RAD51 RAD9A RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SOCS1 SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 VPRBP WRN XPA XRCC5 ZEB1
Entrez ID		9656	472
HPRD ID		16252	06347
Ensembl ID		ENSG00000137337	ENSG00000149311
Uniprot IDs		A1Z5I9 Q14676	Q13315
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cell Cycle Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process Response To Ionizing Radiation Positive Regulation Of Metabolic Process Chromosome Organization Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Response To Radiation Regulation Of Metabolic Process DNA Recombination Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Abiotic Stimulus Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Protein Modification Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process DNA Repair Double-strand Break Repair Cell Cycle Process Cell Cycle Response To Stress DNA Recombination Response To Ionizing Radiation Cell Cycle Checkpoint DNA Damage Checkpoint DNA Replication Response To Radiation Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Regulation Of Cell Cycle Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Cellular Response To Stimulus Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Checkpoint Regulation Of DNA Replication Cellular Metabolic Process Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Difference) ?		53bp1 break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Intersection) ?		atm