SMC1A and NDC80

Number of citations of the paper that reports this interaction (PMID 9295362)
12

Data Source:
HPRD (two hybrid, in vitro)

		SMC1A	NDC80
Gene Name		structural maintenance of chromosomes 1A	NDC80 kinetochore complex component
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Cohesin Core Heterodimer Meiotic Cohesin Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle MRNA Splicing, Via Spliceosome DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division RNA Splicing Response To Radiation Gene Expression Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Signal Transduction In Response To DNA Damage Cell Division	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Establishment of Sister Chromatid Cohesion Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin mRNA Splicing - Major Pathway Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ATM BLM BRCA1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		8243	10403
HPRD ID		02077	06277
Ensembl ID		ENSG00000072501	ENSG00000080986
Uniprot IDs		Q14683 Q68EN4	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Cell Cycle Mitotic Cell Cycle DNA Recombination Mitotic Cell Cycle Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Double-strand Break Repair Organelle Organization Cellular Response To Stress Meiotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Chromosome Organization DNA Strand Elongation DNA-dependent DNA Replication DNA Replication DNA Damage Checkpoint Meiotic Nuclear Division Telomere Maintenance Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Meiosis I DNA Replication Initiation Response To Stress Meiotic Mismatch Repair Nitrogen Compound Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Reciprocal Meiotic Recombination Mitotic Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway Response To Radiation Regulation Of DNA Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation DNA Duplex Unwinding DNA Geometric Change	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?