MDC1 and PIAS4

Number of citations of the paper that reports this interaction (PMID 22661230)
32

Data Source:
BioGRID (enzymatic study)

		MDC1	PIAS4
Gene Name		mediator of DNA-damage checkpoint 1	protein inhibitor of activated STAT, 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	DNA Binding Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Intra-S DNA Damage Checkpoint	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		ATM mediated phosphorylation of repair proteins ATM mediated response to DNA double-strand break Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251	75 interactors: ACTN1 ALDOA AR BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TP53 TRIM27 TRIM32 UBE2I UBE2K VIM ZHX1 ZNF512B
Entrez ID		9656	51588
HPRD ID		16252	06910
Ensembl ID		ENSG00000137337
Uniprot IDs		A1Z5I9 Q14676	Q8N2W9
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cell Cycle Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process Response To Ionizing Radiation Positive Regulation Of Metabolic Process Chromosome Organization Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Response To Radiation Regulation Of Metabolic Process DNA Recombination Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Abiotic Stimulus Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Protein Modification Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cellular Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Gene Expression Response To Stimulus Positive Regulation Of Gene Expression Protein Sumoylation DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stress Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Cell Death
Tagcloud ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Difference) ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Intersection) ?