ATM and EXO1

Number of citations of the paper that reports this interaction (PMID 20019063)
40

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ATM	EXO1
Gene Name		ATM serine/threonine kinase	exonuclease 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm Spindle Cytoplasmic Membrane-bounded Vesicle	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Protein Complex Binding Histone Serine Kinase Activity Protein Dimerization Activity Protein N-terminus Binding	DNA Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity Structure-specific DNA Binding Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion DNA Repair Double-strand Break Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Signal Transduction Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation V(D)J Recombination Cellular Response To Heat Histone-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Oocyte Development Neuron Apoptotic Process Histone MRNA Catabolic Process Cellular Response To Gamma Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Regulation Of Cellular Response To Heat	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Fanconi Anemia pathway G2/M Checkpoints Cellular Senescence p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Regulation of the Fanconi anemia pathway Stabilization of p53 p53-Independent DNA Damage Response Homologous recombination repair of replication-independent double-strand breaks p53-Independent G1/S DNA damage checkpoint Double-Strand Break Repair G1/S DNA Damage Checkpoints ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Meiotic recombination ATM mediated response to DNA double-strand break G2/M DNA damage checkpoint Regulation of HSF1-mediated heat shock response Cellular response to heat stress Autodegradation of the E3 ubiquitin ligase COP1 Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Cell Cycle Checkpoints	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS		Melanoma ( 21983787) Response to metformin ( 21186350 21845381)	Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		76 interactors: AATF ABL1 AP1B1 AP2A2 AP2B1 AP3B2 ATR BCL10 BLM BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 CREB1 CSNK1D CXXC5 DAXX DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EXO1 FANCD2 FOXO3 H2AFX HIF1A KAT5 KAT8 LIG4 MCM2 MDC1 MDM2 MDM4 MRE11A NBN PARP1 PEX5 POLR2A PRKDC PTS RAD17 RAD51 RAD9A RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SOCS1 SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 VPRBP WRN XPA XRCC5 ZEB1	15 interactors: ATM KPNA4 KPNB1 MLH1 MSH2 MSH3 PCNA PMS2 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		472	9156
HPRD ID		06347	06932
Ensembl ID		ENSG00000149311	ENSG00000174371
Uniprot IDs		Q13315	Q9UQ84
PDB IDs			3QE9 3QEA 3QEB
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process DNA Repair Double-strand Break Repair Cell Cycle Process Cell Cycle Response To Stress DNA Recombination Response To Ionizing Radiation Cell Cycle Checkpoint DNA Damage Checkpoint DNA Replication Response To Radiation Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Regulation Of Cell Cycle Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Cellular Response To Stimulus Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Checkpoint Regulation Of DNA Replication Cellular Metabolic Process Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Mismatch Repair Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Organelle Organization Protein Targeting DNA Recombination Regulation Of Intracellular Transport Somatic Recombination Of Immunoglobulin Gene Segments Cellular Response To Stimulus Somatic Diversification Of Immunoglobulins Intracellular Signal Transduction Intracellular Protein Transport Regulation Of Apoptotic Process Immunoglobulin Production Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Stimulus Positive Regulation Of Transport Regulation Of Protein Localization System Development Negative Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Membrane Organization Response To Stress Cellular Protein Localization Meiosis I Regulation Of Cellular Component Organization Protein Transport Establishment Of Localization In Cell DNA Repair Establishment Of Protein Localization
Tagcloud ?		absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mlh1 mmr mms msh2 nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Difference) ?		absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mlh1 mmr mms msh2 nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Intersection) ?