ATM and TIPARP

Number of citations of the paper that reports this interaction (PMID 11238919)
20

Data Source:
HPRD (in vivo)

		ATM	TIPARP
Gene Name		ATM serine/threonine kinase	TCDD-inducible poly(ADP-ribose) polymerase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm Spindle Cytoplasmic Membrane-bounded Vesicle	Nucleus
	Molecular Function	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Protein Complex Binding Histone Serine Kinase Activity Protein Dimerization Activity Protein N-terminus Binding	NAD+ ADP-ribosyltransferase Activity Enhancer Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion DNA Repair Double-strand Break Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Signal Transduction Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation V(D)J Recombination Cellular Response To Heat Histone-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Oocyte Development Neuron Apoptotic Process Histone MRNA Catabolic Process Cellular Response To Gamma Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Regulation Of Cellular Response To Heat	Vasculogenesis Kidney Development Protein ADP-ribosylation Nitrogen Compound Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Negative Regulation Of Gene Expression Hemopoiesis Multicellular Organismal Metabolic Process Positive Regulation Of Protein Catabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Palate Development Face Morphogenesis Cellular Response To Organic Cyclic Compound
Pathways		Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Fanconi Anemia pathway G2/M Checkpoints Cellular Senescence p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Regulation of the Fanconi anemia pathway Stabilization of p53 p53-Independent DNA Damage Response Homologous recombination repair of replication-independent double-strand breaks p53-Independent G1/S DNA damage checkpoint Double-Strand Break Repair G1/S DNA Damage Checkpoints ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Meiotic recombination ATM mediated response to DNA double-strand break G2/M DNA damage checkpoint Regulation of HSF1-mediated heat shock response Cellular response to heat stress Autodegradation of the E3 ubiquitin ligase COP1 Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Melanoma ( 21983787) Response to metformin ( 21186350 21845381)	Ovarian cancer ( 20852632)
Protein-Protein Interactions		76 interactors: AATF ABL1 AP1B1 AP2A2 AP2B1 AP3B2 ATR BCL10 BLM BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 CREB1 CSNK1D CXXC5 DAXX DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EXO1 FANCD2 FOXO3 H2AFX HIF1A KAT5 KAT8 LIG4 MCM2 MDC1 MDM2 MDM4 MRE11A NBN PARP1 PEX5 POLR2A PRKDC PTS RAD17 RAD51 RAD9A RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SOCS1 SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 VPRBP WRN XPA XRCC5 ZEB1	2 interactors: ATM XRN2
Entrez ID		472	25976
HPRD ID		06347	18192
Ensembl ID		ENSG00000149311	ENSG00000163659
Uniprot IDs		Q13315	Q05BQ2 Q7Z3E1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process DNA Repair Double-strand Break Repair Cell Cycle Process Cell Cycle Response To Stress DNA Recombination Response To Ionizing Radiation Cell Cycle Checkpoint DNA Damage Checkpoint DNA Replication Response To Radiation Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Regulation Of Cell Cycle Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Cellular Response To Stimulus Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Checkpoint Regulation Of DNA Replication Cellular Metabolic Process Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process	RNA Catabolic Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Aromatic Compound Catabolic Process Pre-B Cell Allelic Exclusion MRNA Metabolic Process Pre-B Cell Differentiation Histone MRNA Catabolic Process Gamete Generation Replicative Senescence Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Immature B Cell Differentiation DNA Damage Induced Protein Phosphorylation Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sexual Reproduction Lipoprotein Catabolic Process Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Macromolecule Catabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of B Cell Proliferation Mitotic G2 DNA Damage Checkpoint Histone-serine Phosphorylation Cellular Response To Gamma Radiation Histone MRNA Metabolic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Reproduction DNA Metabolic Process V(D)J Recombination Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Single Organism Reproductive Process G2 DNA Damage Checkpoint Mitotic Spindle Assembly Checkpoint DNA Catabolic Process, Exonucleolytic Histone Phosphorylation Spindle Assembly Checkpoint Reproductive Process Negative Regulation Of B Cell Activation Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Oocyte Development Oocyte Differentiation Reciprocal Meiotic Recombination Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation
Tagcloud ?		absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood	1a1 acceleration addresses allergen allergenic allergic basophils beas classroom classrooms coagulation cxcl1 cxcl6 cyp cyp1b1 detoxifying endotoxin eu fel hydrocarbons il6 il8 indoor intensified metabolizing outdoor pm polycyclic xenobiotic
Tagcloud (Difference) ?		absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood	1a1 acceleration addresses allergen allergenic allergic basophils beas classroom classrooms coagulation cxcl1 cxcl6 cyp cyp1b1 detoxifying endotoxin eu fel hydrocarbons il6 il8 indoor intensified metabolizing outdoor pm polycyclic xenobiotic
Tagcloud (Intersection) ?