LRP8

Gene Name		low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
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Gene Ontology Annotations	Cellular Component	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Reelin Receptor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Signal Transduction Blood Coagulation Phototransduction, Visible Light Cytokine-mediated Signaling Pathway Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways		Visual phototransduction Platelet homeostasis Platelet sensitization by LDL Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594)
Protein-protein Interactions		19 interactors: ANAPC10 APBA2 APOE APOH CLU DAB1 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		7804
HPRD ID		04002
Ensembl ID
Uniprot IDs		Q14114
PDB IDs		3A7Q
Enriched GO Terms of Interacting Partners?		Regulation Of Beta-amyloid Clearance Membrane Depolarization Regulation Of Signaling Receptor Clustering Regulation Of Cellular Protein Metabolic Process Regulation Of Membrane Potential Positive Regulation Of Catalytic Activity Regulation Of Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Ion Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Catalytic Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Cell-cell Signaling Positive Regulation Of Protein Modification Process Social Behavior Learning Dendrite Development Regulation Of Ion Transmembrane Transporter Activity Behavior Positive Regulation Of Membrane Potential Regulation Of Transmembrane Transporter Activity Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Synaptic Plasticity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering
Tagcloud ?		aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4