VRK2 and CCT4

Number of citations of the paper that reports this interaction (PMID 24298020)
2

Data Source:
BioGRID (pull down)

		VRK2	CCT4
Gene Name		vaccinia related kinase 2	chaperonin containing TCP1, subunit 4 (delta)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane	Zona Pellucida Receptor Complex Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Protein Phosphorylation Endocytosis Regulation Of Cell Shape Viral Process Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport
Pathways			Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS		Schizophrenia ( 19571808)
Protein-Protein Interactions		10 interactors: CCT2 CCT4 CDC42 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 RBX1 TCP1	10 interactors: ACTA1 ACTA2 ACTB CCNE1 CFAP52 PRPF40A RFWD2 RPS6KA1 UBC VRK2
Entrez ID		7444	10575
HPRD ID		03702	05506
Ensembl ID		ENSG00000028116	ENSG00000115484
Uniprot IDs		Q86Y07	B7Z2F4 P50991
PDB IDs		2V62
Enriched GO Terms of Interacting Partners?		Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Toxin Transport Binding Of Sperm To Zona Pellucida Sperm-egg Recognition 'de Novo' Posttranslational Protein Folding MAPK Cascade 'de Novo' Protein Folding Cell-cell Recognition Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JUN Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cell Recognition Positive Regulation Of JNK Cascade Single Fertilization Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Fertilization Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Protein Folding Cellular Response To Stress Regulation Of MAP Kinase Activity Sexual Reproduction Regulation Of Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway	Cell Cycle Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Toll-like Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Positive Regulation Of Hepatic Stellate Cell Activation Signal Transduction By P53 Class Mediator Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Innate Immune Response-activating Signal Transduction Regulation Of Cell Cycle G1/S Phase Transition Response To Stimulus Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Immune Response Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Movement Of Cell Or Subcellular Component G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified	20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Difference) ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified	20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Intersection) ?