GRHPR and GLS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GRHPR	GLS2
Gene Name		glyoxylate reductase/hydroxypyruvate reductase	glutaminase 2 (liver, mitochondrial)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisomal Matrix Cytosol Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Glycerate Dehydrogenase Activity Hydroxypyruvate Reductase Activity Glyoxylate Reductase (NADP) Activity Carboxylic Acid Binding Protein Homodimerization Activity NAD Binding NADPH Binding	Glutaminase Activity Protein Binding
	Biological Process	Excretion Metabolic Process Cellular Nitrogen Compound Metabolic Process Dicarboxylic Acid Metabolic Process Small Molecule Metabolic Process Glyoxylate Metabolic Process Protein Oligomerization Oxidation-reduction Process	Cellular Amino Acid Metabolic Process Glutamine Metabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process
Pathways		Glyoxylate metabolism Metabolism of amino acids and derivatives	Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS			Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037)
Protein-Protein Interactions		6 interactors: CDC7 FOS GLS2 LIG4 LSM1 PTH2R	11 interactors: CASK DLG1 DLG2 DLG3 DLG4 GRHPR INADL PAG1 RGS3 SNTA1 TAX1BP3
Entrez ID		9380	27165
HPRD ID		05052	05901
Ensembl ID		ENSG00000137106	ENSG00000135423
Uniprot IDs		Q9UBQ7	Q9UI32
PDB IDs		2GCG 2H1S 2Q50 2WWR	4BQM
Enriched GO Terms of Interacting Partners?		DNA Ligation Involved In DNA Recombination DNA-dependent DNA Replication Cellular Response To Metal Ion Double-strand Break Repair Via Break-induced Replication Cellular Response To Inorganic Substance Double-strand Break Repair Positive Regulation Of Nuclear Cell Cycle DNA Replication Lagging Strand Elongation Pro-B Cell Differentiation Conditioned Taste Aversion DNA Recombination DNA Metabolic Process Establishment Of Integrated Proviral Latency DNA Replication Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cellular Nitrogen Compound Metabolic Process Immunoglobulin V(D)J Recombination Establishment Of Viral Latency Histone MRNA Catabolic Process T Cell Receptor V(D)J Recombination Regulation Of Nuclear Cell Cycle DNA Replication DNA Ligation Involved In DNA Repair Response To Metal Ion Lymphoid Progenitor Cell Differentiation Nitrogen Compound Metabolic Process DNA Ligation Sleep Response To Gravity Positive Regulation Of DNA-dependent DNA Replication Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Cellular Response To Stress Cell Division Response To Radiation Histone MRNA Metabolic Process Response To Inorganic Substance Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Immobilization Stress Glutamate Secretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Osteoclast Differentiation Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Synaptic Transmission Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Tight Junction Assembly Small Molecule Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Membrane Organization Negative Regulation Of Dephosphorylation Regulation Of Vasoconstriction By Circulating Norepinephrine Apical Junction Assembly Cell-cell Signaling Axon Guidance Negative Regulation Of T Cell Activation Phosphorylation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phosphatase Activity Negative Regulation Of Homotypic Cell-cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Metabolic Process Axonogenesis Regulation Of Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Negative Regulation Of Leukocyte Activation Chemotaxis Regulation Of Cell Adhesion
Tagcloud ?			alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces
Tagcloud (Difference) ?			alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces
Tagcloud (Intersection) ?