CCKAR and CCK

Number of citations of the paper that reports this interaction (PMID 9603948)
11

Data Source:
HPRD (in vivo, in vitro)

		CCKAR	CCK
Gene Name		cholecystokinin A receptor	cholecystokinin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon
	Molecular Function	Cholecystokinin Receptor Activity Peptide Binding	Hormone Activity Neuropeptide Hormone Activity Protein Binding
	Biological Process	Neuron Migration Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axonogenesis Response To Nutrient Digestion Feeding Behavior Forebrain Development Cellular Response To Hormone Stimulus Cholecystokinin Signaling Pathway Regulation Of Hormone Secretion Response To Peptide	Behavioral Fear Response Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Appetite Positive Regulation Of Protein Oligomerization Eating Behavior Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Regulation Of Sensory Perception Of Pain
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Ceruletide
Diseases
GWAS			Body mass index ( 22344221)
Protein-Protein Interactions		3 interactors: CCK CCKBR PPP1R9B	6 interactors: CCKAR CCKBR CPE ENPEP MEP1A MEP1B
Entrez ID		886	885
HPRD ID		00322	00321
Ensembl ID		ENSG00000163394	ENSG00000187094
Uniprot IDs		P32238	P06307 Q6FG82
PDB IDs		1D6G 1HZN 1PB2
Enriched GO Terms of Interacting Partners?		Feeding Behavior Regulation Of Phosphorylation Regulation Of Opioid Receptor Signaling Pathway Cholecystokinin Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cellular Response To Morphine Regulation Of Cell Growth By Extracellular Stimulus Cellular Response To Isoquinoline Alkaloid Regulation Of Catalytic Activity Response To Extracellular Stimulus Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Appetite Gastric Acid Secretion Regulation Of Exit From Mitosis Behavior Filopodium Assembly Regulation Of Mitochondrial Depolarization Regulation Of Response To Food Positive Regulation Of Protein Oligomerization Cellular Response To Ammonium Ion Regulation Of Appetite Regulation Of Sensory Perception Of Pain Neuron Projection Development Regulation Of Protein Oligomerization Positive Regulation Of Cell Proliferation Cell Migration Eating Behavior Release Of Cytochrome C From Mitochondria Cell Motility Regulation Of Membrane Depolarization Behavioral Fear Response Neuron Development Cellular Response To Alkaloid Response To Morphine Fear Response System Development Regulation Of Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Differentiation G-protein Coupled Receptor Signaling Pathway Cell Projection Organization Regulation Of Neurological System Process Regulation Of Lipid Kinase Activity Acid Secretion Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Locomotion Multicellular Organismal Development Anatomical Structure Development	Digestion Cholecystokinin Signaling Pathway Peptide Hormone Processing Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Proteolysis Feeding Behavior Peptide Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Catabolic Process In Blood Hormone Metabolic Process Cytosolic Calcium Ion Homeostasis Multicellular Organismal Protein Catabolic Process Insulin Processing Multicellular Organismal Protein Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Insulin Metabolic Process Calcium Ion Homeostasis Gastric Acid Secretion Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Organ Development Peptide Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cardiac Left Ventricle Morphogenesis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Cellular Chemical Homeostasis Ion Homeostasis Behavior Toxin Transport System Development Cellular Homeostasis Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Acid Secretion Glomerulus Development Anatomical Structure Morphogenesis Multicellular Organismal Development Cell Migration Chemical Homeostasis Cardiac Ventricle Morphogenesis Cardiovascular System Development
Tagcloud ?		afferent amphetamine cart cascades coadministration cocaine colocalization egr electroporation feeding firing ganglia hairpin hypothalamus lentiviral leptin lrbs mediating neurotransmitter ng nodose ope satiety short silencing synergistically vagal	125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded
Tagcloud (Difference) ?		afferent amphetamine cart cascades coadministration cocaine colocalization egr electroporation feeding firing ganglia hairpin hypothalamus lentiviral leptin lrbs mediating neurotransmitter ng nodose ope satiety short silencing synergistically vagal	125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded
Tagcloud (Intersection) ?