CCKAR and CCKBR

Number of citations of the paper that reports this interaction (PMID 14534299)
20

Data Source:
HPRD (in vitro)

		CCKAR	CCKBR
Gene Name		cholecystokinin A receptor	cholecystokinin B receptor
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Cholecystokinin Receptor Activity Peptide Binding	Phosphatidylinositol Phospholipase C Activity Cholecystokinin Receptor Activity Protein Binding Gastrin Receptor Activity Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Neuron Migration Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axonogenesis Response To Nutrient Digestion Feeding Behavior Forebrain Development Cellular Response To Hormone Stimulus Cholecystokinin Signaling Pathway Regulation Of Hormone Secretion Response To Peptide	Gastric Acid Secretion Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Digestion Sensory Perception Feeding Behavior Metabolic Process Cell Proliferation Positive Regulation Of Cell Proliferation Cholecystokinin Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Digestive Tract Development Gland Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Ceruletide	Pentagastrin
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CCK CCKBR PPP1R9B	7 interactors: ADRB2 ATP13A2 CCK CCKAR NTM PPP1R9B PTPN11
Entrez ID		886	887
HPRD ID		00322	00323
Ensembl ID		ENSG00000163394	ENSG00000110148
Uniprot IDs		P32238	P32239
PDB IDs		1D6G 1HZN 1PB2	1L4T
Enriched GO Terms of Interacting Partners?		Feeding Behavior Regulation Of Phosphorylation Regulation Of Opioid Receptor Signaling Pathway Cholecystokinin Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cellular Response To Morphine Regulation Of Cell Growth By Extracellular Stimulus Cellular Response To Isoquinoline Alkaloid Regulation Of Catalytic Activity Response To Extracellular Stimulus Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Appetite Gastric Acid Secretion Regulation Of Exit From Mitosis Behavior Filopodium Assembly Regulation Of Mitochondrial Depolarization Regulation Of Response To Food Positive Regulation Of Protein Oligomerization Cellular Response To Ammonium Ion Regulation Of Appetite Regulation Of Sensory Perception Of Pain Neuron Projection Development Regulation Of Protein Oligomerization Positive Regulation Of Cell Proliferation Cell Migration Eating Behavior Release Of Cytochrome C From Mitochondria Cell Motility Regulation Of Membrane Depolarization Behavioral Fear Response Neuron Development Cellular Response To Alkaloid Response To Morphine Fear Response System Development Regulation Of Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Neuron Differentiation G-protein Coupled Receptor Signaling Pathway Cell Projection Organization Regulation Of Neurological System Process Regulation Of Lipid Kinase Activity Acid Secretion Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Locomotion Multicellular Organismal Development Anatomical Structure Development	Neuron Development Neuron Differentiation Response To Extracellular Stimulus Generation Of Neurons Neurogenesis Neuron Projection Development Cell Development Response To External Stimulus Cell Migration Cell Differentiation Cell Motility Regulation Of Protein Phosphorylation Nervous System Development Cell Projection Organization Response To Nutrient Levels Locomotion Regulation Of Phosphorylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Feeding Behavior Axonogenesis Regulation Of Multicellular Organism Growth Axon Development Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Growth Cholecystokinin Signaling Pathway Regulation Of Opioid Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Neuron Projection Morphogenesis Abortive Mitotic Cell Cycle Cellular Response To Morphine Negative Regulation Of Glucocorticoid Secretion Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Developmental Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Neuron Migration Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Response To Organonitrogen Compound Regulation Of Cellular Protein Metabolic Process Cellular Response To Manganese Ion Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Protein Modification Process Heat Generation
Tagcloud ?		afferent amphetamine cart cascades coadministration cocaine colocalization egr electroporation feeding firing ganglia hairpin hypothalamus lentiviral leptin lrbs mediating neurotransmitter ng nodose ope satiety short silencing synergistically vagal	13qter 9p acp5 cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?		afferent amphetamine cart cascades coadministration cocaine colocalization egr electroporation feeding firing ganglia hairpin hypothalamus lentiviral leptin lrbs mediating neurotransmitter ng nodose ope satiety short silencing synergistically vagal	13qter 9p acp5 cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?