CCK and CCKBR

Number of citations of the paper that reports this interaction (PMID 15520004)
8

Data Source:
HPRD (in vivo, in vitro)

		CCK	CCKBR
Gene Name		cholecystokinin	cholecystokinin B receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding	Phosphatidylinositol Phospholipase C Activity Cholecystokinin Receptor Activity Protein Binding Gastrin Receptor Activity Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Behavioral Fear Response Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Appetite Positive Regulation Of Protein Oligomerization Eating Behavior Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Regulation Of Sensory Perception Of Pain	Gastric Acid Secretion Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Digestion Sensory Perception Feeding Behavior Metabolic Process Cell Proliferation Positive Regulation Of Cell Proliferation Cholecystokinin Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Digestive Tract Development Gland Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Pentagastrin
Diseases
GWAS		Body mass index ( 22344221)
Protein-Protein Interactions		6 interactors: CCKAR CCKBR CPE ENPEP MEP1A MEP1B	7 interactors: ADRB2 ATP13A2 CCK CCKAR NTM PPP1R9B PTPN11
Entrez ID		885	887
HPRD ID		00321	00323
Ensembl ID		ENSG00000187094	ENSG00000110148
Uniprot IDs		P06307 Q6FG82	P32239
PDB IDs			1L4T
Enriched GO Terms of Interacting Partners?		Digestion Cholecystokinin Signaling Pathway Peptide Hormone Processing Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Proteolysis Feeding Behavior Peptide Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Catabolic Process In Blood Hormone Metabolic Process Cytosolic Calcium Ion Homeostasis Multicellular Organismal Protein Catabolic Process Insulin Processing Multicellular Organismal Protein Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Insulin Metabolic Process Calcium Ion Homeostasis Gastric Acid Secretion Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Organ Development Peptide Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cardiac Left Ventricle Morphogenesis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Cellular Chemical Homeostasis Ion Homeostasis Behavior Toxin Transport System Development Cellular Homeostasis Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Acid Secretion Glomerulus Development Anatomical Structure Morphogenesis Multicellular Organismal Development Cell Migration Chemical Homeostasis Cardiac Ventricle Morphogenesis Cardiovascular System Development	Neuron Development Neuron Differentiation Response To Extracellular Stimulus Generation Of Neurons Neurogenesis Neuron Projection Development Cell Development Response To External Stimulus Cell Migration Cell Differentiation Cell Motility Regulation Of Protein Phosphorylation Nervous System Development Cell Projection Organization Response To Nutrient Levels Locomotion Regulation Of Phosphorylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Feeding Behavior Axonogenesis Regulation Of Multicellular Organism Growth Axon Development Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Growth Cholecystokinin Signaling Pathway Regulation Of Opioid Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Neuron Projection Morphogenesis Abortive Mitotic Cell Cycle Cellular Response To Morphine Negative Regulation Of Glucocorticoid Secretion Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Developmental Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Neuron Migration Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Response To Organonitrogen Compound Regulation Of Cellular Protein Metabolic Process Cellular Response To Manganese Ion Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Protein Modification Process Heat Generation
Tagcloud ?		125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded	13qter 9p acp5 cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?		125i amounted bmax competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded	13qter 9p acp5 chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?		cholecystokinin