CCK and MEP1B

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		CCK	MEP1B
Gene Name		cholecystokinin	meprin A, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Behavioral Fear Response Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Appetite Positive Regulation Of Protein Oligomerization Eating Behavior Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Regulation Of Sensory Perception Of Pain	Proteolysis Inflammatory Response Digestion Toxin Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Body mass index ( 22344221)
Protein-Protein Interactions		6 interactors: CCKAR CCKBR CPE ENPEP MEP1A MEP1B	12 interactors: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT
Entrez ID		885	4225
HPRD ID		00321	02667
Ensembl ID		ENSG00000187094	ENSG00000141434
Uniprot IDs		P06307 Q6FG82	J3QKX5 Q16820
PDB IDs			4GWM 4GWN
Enriched GO Terms of Interacting Partners?		Digestion Cholecystokinin Signaling Pathway Peptide Hormone Processing Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Proteolysis Feeding Behavior Peptide Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Catabolic Process In Blood Hormone Metabolic Process Cytosolic Calcium Ion Homeostasis Multicellular Organismal Protein Catabolic Process Insulin Processing Multicellular Organismal Protein Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Insulin Metabolic Process Calcium Ion Homeostasis Gastric Acid Secretion Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Organ Development Peptide Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cardiac Left Ventricle Morphogenesis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Cellular Chemical Homeostasis Ion Homeostasis Behavior Toxin Transport System Development Cellular Homeostasis Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Acid Secretion Glomerulus Development Anatomical Structure Morphogenesis Multicellular Organismal Development Cell Migration Chemical Homeostasis Cardiac Ventricle Morphogenesis Cardiovascular System Development	Feeding Behavior Regulation Of Appetite Digestion G-protein Coupled Receptor Signaling Pathway Behavior Negative Regulation Of Glial Cell Apoptotic Process Neuropeptide Signaling Pathway Regulation Of Platelet Aggregation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Response To Food Response To Nutrient Levels Regulation Of Protein Binding Response To Extracellular Stimulus Response To Stimulus Regulation Of Cellular Ketone Metabolic Process Regulation Of Platelet Activation Eating Behavior Platelet Activation Response To External Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Body Fluid Levels Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Binding Activation Of Phospholipase C Activity Cell Proliferation Response To Glucagon Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process
Tagcloud ?		125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Difference) ?		125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Intersection) ?