CCK and ENPEP

Number of citations of the paper that reports this interaction (PMID 8804068)
9

Data Source:
HPRD (in vivo, in vitro)

		CCK	ENPEP
Gene Name		cholecystokinin	glutamyl aminopeptidase (aminopeptidase A)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border External Side Of Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding	Aminopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Metalloaminopeptidase Activity
	Biological Process	Behavioral Fear Response Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Appetite Positive Regulation Of Protein Oligomerization Eating Behavior Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Regulation Of Sensory Perception Of Pain	Angiogenesis Angiotensin Maturation Angiotensin Catabolic Process In Blood Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Cell-cell Signaling Cell Proliferation Cell Migration Glomerulus Development Cellular Protein Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs
Diseases
GWAS		Body mass index ( 22344221)	Atrial fibrillation/atrial flutter ( 17603472) Blood pressure ( 21572416) Metabolic traits ( 21886157)
Protein-Protein Interactions		6 interactors: CCKAR CCKBR CPE ENPEP MEP1A MEP1B	2 interactors: AGT CCK
Entrez ID		885	2028
HPRD ID		00321	08848
Ensembl ID		ENSG00000187094
Uniprot IDs		P06307 Q6FG82	Q07075
PDB IDs			4KX7 4KX8 4KX9 4KXA 4KXB 4KXC 4KXD
Enriched GO Terms of Interacting Partners?		Digestion Cholecystokinin Signaling Pathway Peptide Hormone Processing Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Proteolysis Feeding Behavior Peptide Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Catabolic Process In Blood Hormone Metabolic Process Cytosolic Calcium Ion Homeostasis Multicellular Organismal Protein Catabolic Process Insulin Processing Multicellular Organismal Protein Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Insulin Metabolic Process Calcium Ion Homeostasis Gastric Acid Secretion Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Organ Development Peptide Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cardiac Left Ventricle Morphogenesis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Cellular Chemical Homeostasis Ion Homeostasis Behavior Toxin Transport System Development Cellular Homeostasis Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Acid Secretion Glomerulus Development Anatomical Structure Morphogenesis Multicellular Organismal Development Cell Migration Chemical Homeostasis Cardiac Ventricle Morphogenesis Cardiovascular System Development	Regulation Of Neurological System Process Feeding Behavior Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Ion Homeostasis Regulation Of Peptidyl-tyrosine Phosphorylation Uterine Smooth Muscle Contraction Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Protein Processing Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Catenin Import Into Nucleus Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Angiotensin-mediated Drinking Behavior Regulation Of Renal Output By Angiotensin Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Fibroblast Proliferation Astrocyte Activation Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Cellular Ketone Metabolic Process Establishment Of Blood-nerve Barrier Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Activation Of Janus Kinase Activity Drinking Behavior Artery Smooth Muscle Contraction Positive Regulation Of Apoptotic Process Behavior Positive Regulation Of Programmed Cell Death Tonic Smooth Muscle Contraction Brain Renin-angiotensin System Positive Regulation Of Cell Death Positive Regulation Of Cholesterol Esterification Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Superoxide Anion Generation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Mitochondrial Depolarization Regulation Of Cholesterol Esterification Negative Regulation Of Appetite
Tagcloud ?		125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded
Tagcloud (Difference) ?		125i amounted bmax cholecystokinin competitive dependently displaced disuccinimidyl endocrine enteroendocrine hour igf intestinal linking mediation monolayers mr nm page polypeptide potencies scatchard sds stc suberate synthesizes thymidine unlabeled yielded
Tagcloud (Intersection) ?