BHLHE40 and BHLHE41

Number of citations of the paper that reports this interaction (PMID 15560782)
15

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		BHLHE40	BHLHE41
Gene Name		basic helix-loop-helix family, member e40	basic helix-loop-helix family, member e41
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Golgi Apparatus	Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Circadian Rhythm Cell Proliferation Organ Morphogenesis Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Cell Differentiation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: AAMP AANAT AES APH1A ARNTL BHLHE41 BRD7 BTRC CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 FBXW11 GMCL1P1 HDAC1 HIVEP1 KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMYD1 SOX15 STAT3 STK19 TOB2 TOLLIP TTC23 TXNL4B VAC14 VIM ZHX1	3 interactors: BHLHE40 MYOD1 SIRT1
Entrez ID		8553	79365
HPRD ID		16050	16204
Ensembl ID		ENSG00000134107	ENSG00000123095
Uniprot IDs		O14503 Q6IB83	B7Z8M6 Q8TAT1 Q9C0J9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process RNA Metabolic Process Regulation Of Circadian Rhythm Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Histone Modification Chromatin Modification Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Protein Metabolic Process Developmental Process Chromosome Organization Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Protein Acetylation Biosynthetic Process	Circadian Regulation Of Gene Expression Cellular Response To Oxygen Levels Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Peptidyl-lysine Acetylation Protein Acetylation Cellular Response To Starvation Response To Abiotic Stimulus Establishment Of Chromatin Silencing Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Cellular Response To Testosterone Stimulus Circadian Rhythm Cellular Response To Nutrient Levels Response To Starvation Myoblast Fate Determination Behavioral Response To Starvation Myotube Differentiation Involved In Skeletal Muscle Regeneration Skeletal Muscle Fiber Adaptation Cellular Response To Extracellular Stimulus Peptidyl-lysine Modification Maintenance Of Chromatin Silencing Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Chromatin Silencing Muscle Organ Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Cellular Senescence Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Skeletal Muscle Tissue Regeneration Pyrimidine Dimer Repair By Nucleotide-excision Repair Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Skeletal Muscle Fiber Development Histone Modification Peptidyl-lysine Deacetylation Methylation-dependent Chromatin Silencing Negative Regulation Of CAMP-dependent Protein Kinase Activity Myoblast Fate Commitment Positive Regulation Of MHC Class II Biosynthetic Process Transcription, DNA-templated Response To Nutrient Levels Positive Regulation Of Cell Aging Triglyceride Mobilization Cellular Triglyceride Homeostasis Response To Radiation RNA Biosynthetic Process Skeletal Muscle Adaptation Negative Regulation Of Cellular Senescence Response To Extracellular Stimulus
Tagcloud ?		ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts
Tagcloud (Difference) ?		ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts
Tagcloud (Intersection) ?