BHLHE40 and COX5B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		BHLHE40	COX5B
Gene Name		basic helix-loop-helix family, member e40	cytochrome c oxidase subunit Vb
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Golgi Apparatus	Mitochondrion Mitochondrial Inner Membrane Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	Cytochrome-c Oxidase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated	Respiratory Gaseous Exchange Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: AAMP AANAT AES APH1A ARNTL BHLHE41 BRD7 BTRC CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 FBXW11 GMCL1P1 HDAC1 HIVEP1 KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMYD1 SOX15 STAT3 STK19 TOB2 TOLLIP TTC23 TXNL4B VAC14 VIM ZHX1	11 interactors: AR BHLHE40 CCDC36 CDR2 KRT15 KRT31 LSM4 PNMA1 TFIP11 TRAF1 TRIM23
Entrez ID		8553	1329
HPRD ID		16050	00467
Ensembl ID		ENSG00000134107
Uniprot IDs		O14503 Q6IB83	P10606
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process RNA Metabolic Process Regulation Of Circadian Rhythm Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Histone Modification Chromatin Modification Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Protein Metabolic Process Developmental Process Chromosome Organization Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Protein Acetylation Biosynthetic Process	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Integrin Biosynthetic Process Spliceosomal Complex Disassembly Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Integrin Biosynthetic Process Regulation Of Integrin Biosynthetic Process
Tagcloud ?		ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts	acidosis adaption adjunct analogous antitumoral carcinomas cd147 depend exists fulfillment glut1 glycolysis hnscc hpv immunological lactate lactic metabolite metabolize microenvironment oropharyngeal postulated returned situation sparse stronger transmembranous transportation warburg
Tagcloud (Difference) ?		ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts	acidosis adaption adjunct analogous antitumoral carcinomas cd147 depend exists fulfillment glut1 glycolysis hnscc hpv immunological lactic metabolite metabolize microenvironment oropharyngeal postulated returned situation sparse stronger transmembranous transportation warburg
Tagcloud (Intersection) ?		lactate