BHLHE41 and MYOD1

Number of citations of the paper that reports this interaction (PMID 12657651)
20

Data Source:
HPRD (in vitro)

		BHLHE41	MYOD1
Gene Name		basic helix-loop-helix family, member e41	myogenic differentiation 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Myofibril
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Nuclear Hormone Receptor Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Circadian Rhythm Cell Proliferation Organ Morphogenesis Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Cell Differentiation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Cellular Response To Starvation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Muscle Cell Differentiation Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: BHLHE40 MYOD1 SIRT1	61 interactors: ASCL3 BHLHA15 BHLHE40 BHLHE41 C2orf88 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 HAND1 HDAC1 HEY1 HIST1H3A HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 JUN KAT2B KAT5 KPNA3 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF3 TCF4 TWIST1
Entrez ID		79365	4654
HPRD ID		16204	01166
Ensembl ID		ENSG00000123095	ENSG00000129152
Uniprot IDs		B7Z8M6 Q8TAT1 Q9C0J9	P15172
PDB IDs
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Cellular Response To Oxygen Levels Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Peptidyl-lysine Acetylation Protein Acetylation Cellular Response To Starvation Response To Abiotic Stimulus Establishment Of Chromatin Silencing Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Cellular Response To Testosterone Stimulus Circadian Rhythm Cellular Response To Nutrient Levels Response To Starvation Myoblast Fate Determination Behavioral Response To Starvation Myotube Differentiation Involved In Skeletal Muscle Regeneration Skeletal Muscle Fiber Adaptation Cellular Response To Extracellular Stimulus Peptidyl-lysine Modification Maintenance Of Chromatin Silencing Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Chromatin Silencing Muscle Organ Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Cellular Senescence Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Skeletal Muscle Tissue Regeneration Pyrimidine Dimer Repair By Nucleotide-excision Repair Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Skeletal Muscle Fiber Development Histone Modification Peptidyl-lysine Deacetylation Methylation-dependent Chromatin Silencing Negative Regulation Of CAMP-dependent Protein Kinase Activity Myoblast Fate Commitment Positive Regulation Of MHC Class II Biosynthetic Process Transcription, DNA-templated Response To Nutrient Levels Positive Regulation Of Cell Aging Triglyceride Mobilization Cellular Triglyceride Homeostasis Response To Radiation RNA Biosynthetic Process Skeletal Muscle Adaptation Negative Regulation Of Cellular Senescence Response To Extracellular Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Rhythmic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Organ Development Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Anatomical Structure Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Organ Morphogenesis Anatomical Structure Development Cardiovascular System Development Regulation Of Cell Differentiation Heart Development Response To Growth Factor Biosynthetic Process Regulation Of Cell Cycle Developmental Process Cell Differentiation System Development Regulation Of Binding
Tagcloud ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?