BHLHE40 and AANAT

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		BHLHE40	AANAT
Gene Name		basic helix-loop-helix family, member e40	aralkylamine N-acetyltransferase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Golgi Apparatus	Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	Aralkylamine N-acetyltransferase Activity Arylamine N-acetyltransferase Activity 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated	N-terminal Protein Amino Acid Acetylation Circadian Rhythm Response To Light Stimulus Response To Zinc Ion Melatonin Biosynthetic Process Response To Insulin Response To Cytokine Cellular Nitrogen Compound Metabolic Process Response To Prostaglandin E Small Molecule Metabolic Process Indolalkylamine Biosynthetic Process Response To Copper Ion Response To Corticosterone Response To Calcium Ion Cellular Response To CAMP
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	Amine-derived hormones Serotonin and melatonin biosynthesis Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: AAMP AANAT AES APH1A ARNTL BHLHE41 BRD7 BTRC CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 FBXW11 GMCL1P1 HDAC1 HIVEP1 KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMYD1 SOX15 STAT3 STK19 TOB2 TOLLIP TTC23 TXNL4B VAC14 VIM ZHX1	5 interactors: BHLHE40 F2 MDFI PRKACA YWHAZ
Entrez ID		8553	15
HPRD ID		16050	02974
Ensembl ID		ENSG00000134107	ENSG00000129673
Uniprot IDs		O14503 Q6IB83	F1T0I5 J3KMZ5 Q16613
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process RNA Metabolic Process Regulation Of Circadian Rhythm Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Histone Modification Chromatin Modification Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Protein Metabolic Process Developmental Process Chromosome Organization Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Protein Acetylation Biosynthetic Process	Regulation Of Intracellular Transport Platelet Activation Positive Regulation Of Intracellular Transport Regulation Of Platelet Activation Regulation Of Cellular Localization Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Establishment Of Protein Localization Cell Activation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Histone H3-T6 Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Ion Homeostasis Positive Regulation Of Protein Modification Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cytosolic Calcium Ion Homeostasis Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Nucleocytoplasmic Transport Golgi Reassembly Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Binding Histamine Secretion By Mast Cell Regulation Of Intracellular Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Peptidyl-serine Autophosphorylation Establishment Of Golgi Localization Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of MAP Kinase Activity
Tagcloud ?		ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts	asmt chordoid circumventricular claudin cldn3 col11a1 cvos dissected epcam ependyma ependymocytes lcm microdissection organum periventricular pineal pole ren1 sco sfo slc22a3 subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial
Tagcloud (Difference) ?		ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts	asmt chordoid circumventricular claudin cldn3 col11a1 cvos dissected epcam ependyma ependymocytes lcm microdissection organum periventricular pineal pole ren1 sco sfo slc22a3 subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial
Tagcloud (Intersection) ?