ACTC1 and DMD

Number of citations of the paper that reports this interaction (PMID 11997265)
18

Data Source:
HPRD (in vivo)

		ACTC1	DMD
Gene Name		actin, alpha, cardiac muscle 1	dystrophin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Cell Junction Filopodium Filopodium Membrane Sarcolemma Costamere Protein Complex Membrane Raft Postsynaptic Membrane
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Nitric-oxide Synthase Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Regulation Of Heart Rate Muscle Organ Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Muscle Filament Sliding Extracellular Matrix Organization Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Peptide Biosynthetic Process Cellular Protein Complex Assembly Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Striated Muscle Contraction	Striated Muscle Contraction Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)	Response to antidepressant treatment ( 22041458)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	27 interactors: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG HAUS1 KCNJ12 KRT19 KRT8 MAP3K5 PGM5 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 UTRN
Entrez ID		70	1756
HPRD ID		00015	02303
Ensembl ID		ENSG00000159251	ENSG00000198947
Uniprot IDs		B3KPP5 P68032	A1L0U9 A7E212 P11532 Q16484 Q4G0X0
PDB IDs			1DXX 1EG3 1EG4 3UUN
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Muscle Contraction Muscle System Process Muscle Cell Development Myofibril Assembly Actomyosin Structure Organization Organelle Assembly Cellular Component Assembly Muscle Structure Development Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Striated Muscle Cell Development Skeletal Myofibril Assembly Synaptic Vesicle Priming Striated Muscle Cell Differentiation Organ Development Cytoskeleton Organization Organelle Organization Muscle Organ Development Positive Regulation Of Proteolysis Cell Development System Development Positive Regulation Of Peptidase Activity Cell Differentiation Involved In Embryonic Placenta Development Actin-myosin Filament Sliding Muscle Filament Sliding Movement Of Cell Or Subcellular Component Regulation Of Sodium Ion Transmembrane Transport Microtubule-based Process Actin-mediated Cell Contraction Programmed Necrotic Cell Death Nerve Maturation Regulation Of Vasoconstriction By Circulating Norepinephrine Necrotic Cell Death Multicellular Organismal Development Sarcomere Organization Neuromuscular Junction Development Synaptic Vesicle Exocytosis Anatomical Structure Development Actin Filament-based Movement Cell-cell Signaling Heart Contraction Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Calcium-dependent Cell-matrix Adhesion Regulation Of Sodium Ion Transport Anatomical Structure Morphogenesis Viral Process Apoptotic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	2gamma chromosome dffry encode escape escapes eutherian homologue homologues identity inactivation kangaroo maps metatherian primates retroposon retroposons shed simian smcy spermatogenesis sxrb ube1y ubiquitously uty xp21 y zfy1 zfy2
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	2gamma chromosome dffry encode escape escapes eutherian homologue homologues identity inactivation kangaroo maps metatherian primates retroposon retroposons shed simian smcy spermatogenesis sxrb ube1y ubiquitously uty xp21 y zfy1 zfy2
Tagcloud (Intersection) ?