ACTC1 and MPC1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ACTC1	MPC1
Gene Name		actin, alpha, cardiac muscle 1	mitochondrial pyruvate carrier 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Cellular_component Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Molecular_function Pyruvate Transmembrane Transporter Activity
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Pyruvate Metabolic Process Mitochondrial Pyruvate Transport Biological_process Cellular Metabolic Process Small Molecule Metabolic Process Pyruvate Transmembrane Transport
Pathways		Striated Muscle Contraction	Pyruvate metabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	3 interactors: ACTC1 GABARAP MAGED1
Entrez ID		70	51660
HPRD ID		00015	07091
Ensembl ID		ENSG00000159251	ENSG00000060762
Uniprot IDs		B3KPP5 P68032	Q5TI65 Q9Y5U8
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Organelle Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Branching Involved In Ureteric Bud Morphogenesis Nucleophagy Cardiac Myofibril Assembly Mitochondrion Degradation Muscle Filament Sliding Actin-myosin Filament Sliding
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	1q12 bmi1 concentrates deacetylation eed ezh2 heritable heterochromatin hmtase homologs hpc hpc2 hph k9 m33 methyltransferase multimeric observe pcg pericentromeric polycomb relocalization repress repression ring1 suv39h1 utilizes vertebrate xpc2
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	1q12 bmi1 concentrates deacetylation eed ezh2 heritable heterochromatin hmtase homologs hpc hpc2 hph k9 m33 methyltransferase multimeric observe pcg pericentromeric polycomb relocalization repress repression ring1 suv39h1 utilizes vertebrate xpc2
Tagcloud (Intersection) ?