ACTC1 and ACTR2

Number of citations of the paper that reports this interaction (PMID 12019562)
9

Data Source:
HPRD (in vivo)

		ACTC1	ACTR2
Gene Name		actin, alpha, cardiac muscle 1	ARP2 actin-related protein 2 homolog (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Actin Cap Cell Projection Extracellular Vesicular Exosome
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Structural Constituent Of Cytoskeleton ATP Binding Actin Filament Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Cytoplasmic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cilium Assembly Innate Immune Response Ephrin Receptor Signaling Pathway Spindle Localization
Pathways		Striated Muscle Contraction	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	13 interactors: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CTTN ELF5 HCLS1 IQGAP2 WASF1 WASF2 WASL
Entrez ID		70	10097
HPRD ID		00015	05023
Ensembl ID		ENSG00000159251	ENSG00000138071
Uniprot IDs		B3KPP5 P68032	P61160
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Actin Filament Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Organelle Organization Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Actin Nucleation Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Actin Polymerization Or Depolymerization Actin Filament Polymerization Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Ephrin Receptor Signaling Pathway Protein Polymerization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Endocytosis Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Actin Filament-based Movement Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Morphogenesis Positive Regulation Of Immune Response
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?