TCP1 and VRK2

Number of citations of the paper that reports this interaction (PMID 24298020)
2

Data Source:
BioGRID (pull down, pull down)

		TCP1	VRK2
Gene Name		t-complex 1	vaccinia related kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Acrosomal Vesicle Zona Pellucida Receptor Complex Nuclear Heterochromatin Golgi Apparatus Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport Regulation Of Macrophage Apoptotic Process	Protein Phosphorylation Endocytosis Regulation Of Cell Shape Viral Process Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS			Schizophrenia ( 19571808)
Protein-Protein Interactions		12 interactors: CBFA2T2 CCT5 CCT7 CDC20 FANCA HSPA8 PDCL SH3BP4 TUBA4A TUBA8 VRK2 YWHAQ	10 interactors: CCT2 CCT4 CDC42 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 RBX1 TCP1
Entrez ID		6950	7444
HPRD ID		01748	03702
Ensembl ID		ENSG00000120438	ENSG00000028116
Uniprot IDs		E7EQR6 F5H282 P17987	Q86Y07
PDB IDs			2V62
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Toxin Transport Regulation Of Cellular Component Organization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Fibril Organization Heterotrimeric G-protein Complex Assembly Protein Polymerization Protein Complex Assembly Regulation Of Fibril Organization Regulation Of Interleukin-1-mediated Signaling Pathway Cell Recognition Single Fertilization Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Refolding Clathrin Coat Disassembly Fertilization Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synaptic Plasticity Vesicle-mediated Transport	Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Toxin Transport Binding Of Sperm To Zona Pellucida Sperm-egg Recognition 'de Novo' Posttranslational Protein Folding MAPK Cascade 'de Novo' Protein Folding Cell-cell Recognition Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JUN Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cell Recognition Positive Regulation Of JNK Cascade Single Fertilization Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Fertilization Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Protein Folding Cellular Response To Stress Regulation Of MAP Kinase Activity Sexual Reproduction Regulation Of Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts	2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Difference) ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts	2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Intersection) ?