TCP1

Gene Name		t-complex 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Acrosomal Vesicle Zona Pellucida Receptor Complex Nuclear Heterochromatin Golgi Apparatus Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport Regulation Of Macrophage Apoptotic Process
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS
Protein-protein Interactions		12 interactors: CBFA2T2 CCT5 CCT7 CDC20 FANCA HSPA8 PDCL SH3BP4 TUBA4A TUBA8 VRK2 YWHAQ
Entrez ID		6950
HPRD ID		01748
Ensembl ID		ENSG00000120438
Uniprot IDs		E7EQR6 F5H282 P17987
PDB IDs
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Toxin Transport Regulation Of Cellular Component Organization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Fibril Organization Heterotrimeric G-protein Complex Assembly Protein Polymerization Protein Complex Assembly Regulation Of Fibril Organization Regulation Of Interleukin-1-mediated Signaling Pathway Cell Recognition Single Fertilization Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Refolding Clathrin Coat Disassembly Fertilization Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synaptic Plasticity Vesicle-mediated Transport
Tagcloud ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts