TCP1 and CCT7

Number of citations of the paper that reports this interaction (PMID 9250675)
29

Data Source:
HPRD (in vitro)

		TCP1	CCT7
Gene Name		t-complex 1	chaperonin containing TCP1, subunit 7 (eta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Acrosomal Vesicle Zona Pellucida Receptor Complex Nuclear Heterochromatin Golgi Apparatus Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome	Zona Pellucida Receptor Complex Cytoplasm Mitochondrion Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding	Protein Binding ATP Binding Identical Protein Binding Unfolded Protein Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport Regulation Of Macrophage Apoptotic Process	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC	Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CBFA2T2 CCT5 CCT7 CDC20 FANCA HSPA8 PDCL SH3BP4 TUBA4A TUBA8 VRK2 YWHAQ	19 interactors: ANXA1 ANXA7 APP ATP5C1 CDKN1A CEBPE CRMP1 DNM2 EEF1G KAT5 KRAS MED31 NKX3-1 PRPF40A RAP1B RCC1 SSSCA1 SUMO4 TCP1
Entrez ID		6950	10574
HPRD ID		01748	06896
Ensembl ID		ENSG00000120438	ENSG00000135624
Uniprot IDs		E7EQR6 F5H282 P17987	Q99832
PDB IDs
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Toxin Transport Regulation Of Cellular Component Organization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Fibril Organization Heterotrimeric G-protein Complex Assembly Protein Polymerization Protein Complex Assembly Regulation Of Fibril Organization Regulation Of Interleukin-1-mediated Signaling Pathway Cell Recognition Single Fertilization Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Refolding Clathrin Coat Disassembly Fertilization Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synaptic Plasticity Vesicle-mediated Transport	Response To Organic Cyclic Compound Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Response To Radiation Response To Steroid Hormone Regulation Of Cell Cycle Process Response To Lipid Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Mitotic Cell Cycle Arrest Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Epithelium Development Positive Regulation Of Cellular Protein Metabolic Process Response To Ionizing Radiation Regulation Of Protein Kinase Activity Cellular Response To Organic Cyclic Compound Cellular Metabolic Process Response To Glucocorticoid Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Response To X-ray Cellular Response To Lipid Response To Corticosteroid Regulation Of Kinase Activity Hemostasis Regulation Of Myeloid Cell Apoptotic Process Anatomical Structure Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Cell Cycle Regulation Of Cellular Component Organization Androgen Receptor Signaling Pathway Social Behavior Intracellular Receptor Signaling Pathway Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Protein Modification Process Response To Stress Regulation Of Apoptotic Process Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Response To Hormone Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway
Tagcloud ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts	adequately cct3 cct5 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Difference) ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts	adequately cct3 cct5 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth
Tagcloud (Intersection) ?