TCP1 and SH3BP4

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		TCP1	SH3BP4
Gene Name		t-complex 1	SH3-domain binding protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Acrosomal Vesicle Zona Pellucida Receptor Complex Nuclear Heterochromatin Golgi Apparatus Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome	Nucleus Cytoplasm Coated Pit Clathrin-coated Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding	GDP-dissociation Inhibitor Activity Protein Binding Ras GTPase Binding Identical Protein Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport Regulation Of Macrophage Apoptotic Process	Endocytosis Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767) Orofacial clefts ( 22419666)
Protein-Protein Interactions		12 interactors: CBFA2T2 CCT5 CCT7 CDC20 FANCA HSPA8 PDCL SH3BP4 TUBA4A TUBA8 VRK2 YWHAQ	21 interactors: C2orf73 CCT3 CEP78 CIZ1 DNAJA4 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 TCP1 TTC1 TXNL1 YWHAE YWHAG ZBTB37
Entrez ID		6950	23677
HPRD ID		01748	09285
Ensembl ID		ENSG00000120438	ENSG00000130147
Uniprot IDs		E7EQR6 F5H282 P17987	Q9P0V3
PDB IDs
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Toxin Transport Regulation Of Cellular Component Organization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Fibril Organization Heterotrimeric G-protein Complex Assembly Protein Polymerization Protein Complex Assembly Regulation Of Fibril Organization Regulation Of Interleukin-1-mediated Signaling Pathway Cell Recognition Single Fertilization Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Refolding Clathrin Coat Disassembly Fertilization Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synaptic Plasticity Vesicle-mediated Transport	Protein Folding Toxin Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Heat G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Binding Of Sperm To Zona Pellucida Protein Localization Substantia Nigra Development Response To Temperature Stimulus Sperm-egg Recognition Steroid Hormone Receptor Complex Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Neural Nucleus Development 'de Novo' Posttranslational Protein Folding Positive Regulation Of Mitochondrion Organization 'de Novo' Protein Folding Cell-cell Recognition Cellular Response To Heat Negative Regulation Of Peptidyl-serine Dephosphorylation Cerebellum Structural Organization Regulation Of Heart Rate By Hormone Mitotic Cell Cycle Process Midbrain Development Positive Regulation Of DNA-dependent DNA Replication Initiation Mitotic Cell Cycle Regulation Of Mitochondrion Organization Cell Recognition Single Fertilization Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of DNA-dependent DNA Replication Initiation Cellular Response To Stress Maintenance Of Protein Location In Cell Regulation Of Cell Death
Tagcloud ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts
Tagcloud (Difference) ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts
Tagcloud (Intersection) ?