GAREM and CRKL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GAREM	CRKL
Gene Name		GRB2 associated, regulator of MAPK1	v-crk avian sarcoma virus CT10 oncogene homolog-like
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Endosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Proline-rich Region Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways			Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CRKL GRB2	71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1
Entrez ID		64762	1399
HPRD ID		12685	03596
Ensembl ID		ENSG00000141441	ENSG00000099942
Uniprot IDs		Q9H706	P46109
PDB IDs		2DKZ	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Parathyroid Gland Development Branching Involved In Labyrinthine Layer Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Labyrinthine Layer Morphogenesis Embryonic Placenta Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Receptor Internalization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stress Labyrinthine Layer Development Cellular Response To Ionizing Radiation Thymus Development Activation Of MAPKK Activity Regulation Of Intracellular Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction T Cell Costimulation Cellular Response To Organic Substance Regulation Of ERBB Signaling Pathway Receptor Metabolic Process JNK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction In Response To DNA Damage	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process
Tagcloud ?		3epsilon adaptor egf encoded erk eventually grb2 homologues localization make mapk1 named neuroblastoma nucleus organs phosphorylated recruited regulates regulator sh shp2 subtype subtypes sy5y tyr tyrosines ubiquitously	actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?		3epsilon egf encoded erk eventually homologues localization make mapk1 named neuroblastoma organs phosphorylated recruited regulates regulator sh shp2 subtype subtypes sy5y tyr tyrosines ubiquitously	actions antiapoptotic behavior believed chemotactic converting crkii focused igfs implicated intracellularly ir irs mediates metabolism mitogenic occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Intersection) ?		adaptor grb2 nucleus