CCL1 and HUWE1

Number of citations of the paper that reports this interaction (PMID 15989956)
126

Data Source:
HPRD (in vitro)

		CCL1	HUWE1
Gene Name		chemokine (C-C motif) ligand 1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Vesicular Exosome
	Molecular Function	Chemokine Activity	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Poly(A) RNA Binding
	Biological Process	Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Signal Transduction Viral Process Cell Chemotaxis	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Histone Ubiquitination Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)
Protein-Protein Interactions		2 interactors: CCR8 HUWE1	20 interactors: ABL1 CALM1 CCL1 CDKN2A HDAC2 LAPTM5 MCL1 MYC PIAS2 POLB RNF11 SMAD2 SMAD9 TP53 UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4
Entrez ID		6346	10075
HPRD ID		01654	06608
Ensembl ID		ENSG00000108702	ENSG00000086758
Uniprot IDs		P22362	Q7Z6Z7
PDB IDs		1EL0	2EKK 3G1N 3H1D
Enriched GO Terms of Interacting Partners?			Transforming Growth Factor Beta Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Stress Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Ubiquitination Signal Transduction Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Signaling Cellular Response To Oxygen Levels Negative Regulation Of Cellular Metabolic Process Cell Communication Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Hypoxia Cellular Macromolecule Catabolic Process Transcription, DNA-templated Cellular Protein Metabolic Process Cell Cycle Arrest Catabolic Process Regulation Of Cell Cycle RNA Biosynthetic Process Intracellular Signal Transduction
Tagcloud ?		aacr adequate aurka aurora bioavailability ccl5 cleared coadministered combining cxcl9 depolarization ends escape harboring leukocytes leverages lifespan mdm2 offers prominent proof rationale rejection reliant res senescence senescent sound therapeutics	attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1
Tagcloud (Difference) ?		aacr adequate aurka aurora bioavailability ccl5 cleared coadministered combining cxcl9 depolarization ends escape harboring leukocytes leverages lifespan mdm2 offers prominent proof rationale rejection reliant res senescence senescent sound therapeutics	attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1
Tagcloud (Intersection) ?