CCL1 and CCR8

Number of citations of the paper that reports this interaction (PMID 9211859)
23

Data Source:
HPRD (in vitro, in vivo)

		CCL1	CCR8
Gene Name		chemokine (C-C motif) ligand 1	chemokine (C-C motif) receptor 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Chemokine Activity	Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity
	Biological Process	Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Signal Transduction Viral Process Cell Chemotaxis	Chemotaxis Immune Response Cell Adhesion G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)
Protein-Protein Interactions		2 interactors: CCR8 HUWE1	6 interactors: CCL1 CCL16 CCL17 CCL4 TPST1 TPST2
Entrez ID		6346	1237
HPRD ID		01654	03497
Ensembl ID		ENSG00000108702	ENSG00000179934
Uniprot IDs		P22362	P51685
PDB IDs		1EL0
Enriched GO Terms of Interacting Partners?			Cell Chemotaxis Peptidyl-tyrosine Sulfation Protein Sulfation Inflammatory Response Sulfation Chemotaxis Cell Migration Cell Motility Locomotion Immune Response Defense Response Movement Of Cell Or Subcellular Component Response To External Stimulus Prevention Of Polyspermy Immune System Process Cell-cell Signaling Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation By Host Of Viral Transcription Sulfur Compound Metabolic Process Fusion Of Sperm To Egg Plasma Membrane Plasma Membrane Fusion Egg Activation Response To Stress Negative Regulation Of Viral Transcription Negative Regulation Of Myoblast Differentiation Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Regulation Of Lymphocyte Migration Interaction With Symbiont Regulation Of Myoblast Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Leukocyte Chemotaxis
Tagcloud ?		aacr adequate aurka aurora bioavailability ccl5 cleared coadministered combining cxcl9 depolarization ends escape harboring leukocytes leverages lifespan mdm2 offers prominent proof rationale rejection reliant res senescence senescent sound therapeutics	3p21 bimodal call chemokine chemokines chemotaxis chemr1 ckr cloning cxcr1 cxcr4 faint freshly l1 leukocytes lymphocytes mobilization nomenclature phytohemagglutinin responsiveness served stably stromal subnanomolar ter1 termed transfected unusual
Tagcloud (Difference) ?		aacr adequate aurka aurora bioavailability ccl5 cleared coadministered combining cxcl9 depolarization ends escape harboring leverages lifespan mdm2 offers prominent proof rationale rejection reliant res senescence senescent sound therapeutics	3p21 bimodal call chemokine chemokines chemotaxis chemr1 ckr cloning cxcr1 cxcr4 faint freshly l1 lymphocytes mobilization nomenclature phytohemagglutinin responsiveness served stably stromal subnanomolar ter1 termed transfected unusual
Tagcloud (Intersection) ?		leukocytes