HUWE1 and UBE2L3

Number of citations of the paper that reports this interaction (PMID 9575161)
24

Data Source:
BioGRID (pull down)

		HUWE1	UBE2L3
Gene Name		HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2L 3
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Poly(A) RNA Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Histone Ubiquitination Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) HDL cholesterol ( 20686565) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 21408207 19838193)
Protein-Protein Interactions		20 interactors: ABL1 CALM1 CCL1 CDKN2A HDAC2 LAPTM5 MCL1 MYC PIAS2 POLB RNF11 SMAD2 SMAD9 TP53 UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4	64 interactors: ARIH1 ARIH2 ATXN3 BRCA1 CBL CBLC CCNB1IP1 CUL9 DTX3 FBXO2 FOS HACE1 HERC3 HSPA4 HUWE1 ITCH LIG4 MAPK6 MDM2 MID1 MKRN3 MUL1 NEDD4 NEDD4L NFKBIA NR3C1 PARK2 PJA1 POLR2A PTEN RAD23A RBCK1 RBX1 RELA RNF103 RNF113B RNF125 RNF144A RNF144B RNF19A RNF2 RNF216 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TRAF6 TRAF7 TRIM21 TRIM28 TRIM39 TRIP12 UBA1 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR5 WWP1 WWP2
Entrez ID		10075	7332
HPRD ID		06608	04762
Ensembl ID		ENSG00000086758	ENSG00000185651
Uniprot IDs		Q7Z6Z7	P68036
PDB IDs		2EKK 3G1N 3H1D	1C4Z 1FBV 3SQV 3SY2
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Stress Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Ubiquitination Signal Transduction Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Signaling Cellular Response To Oxygen Levels Negative Regulation Of Cellular Metabolic Process Cell Communication Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Hypoxia Cellular Macromolecule Catabolic Process Transcription, DNA-templated Cellular Protein Metabolic Process Cell Cycle Arrest Catabolic Process Regulation Of Cell Cycle RNA Biosynthetic Process Intracellular Signal Transduction	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Polyubiquitination Proteolysis Protein Metabolic Process Catabolic Process Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Viral Process Regulation Of Protein Catabolic Process Cellular Response To Organic Substance Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Protein K48-linked Ubiquitination Negative Regulation Of Signaling Protein Monoubiquitination Cellular Response To Stress Metabolic Process Protein Autoubiquitination Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Organic Substance Response To Growth Factor Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cytokine Production Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Positive Regulation Of Protein Catabolic Process
Tagcloud ?		attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1	2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Difference) ?		attractive bicyclic biol catalyze chem cys displacement druggable e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1	2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Intersection) ?		e2