HUWE1 and LAPTM5

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		HUWE1	LAPTM5
Gene Name		HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	lysosomal protein transmembrane 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Vesicular Exosome	Lysosome Lysosomal Membrane Integral Component Of Plasma Membrane
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Poly(A) RNA Binding
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Histone Ubiquitination Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ABL1 CALM1 CCL1 CDKN2A HDAC2 LAPTM5 MCL1 MYC PIAS2 POLB RNF11 SMAD2 SMAD9 TP53 UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4	25 interactors: ANKRD13A DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 HERC1 HEY1 HEYL HUWE1 ITCH KRT7 LDLRAD1 NEDD4 NEDD4L RNF168 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC USP13 WWP1
Entrez ID		10075	7805
HPRD ID		06608	03280
Ensembl ID		ENSG00000086758	ENSG00000162511
Uniprot IDs		Q7Z6Z7	Q13571 Q5TBB8
PDB IDs		2EKK 3G1N 3H1D
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Stress Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Ubiquitination Signal Transduction Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Signaling Cellular Response To Oxygen Levels Negative Regulation Of Cellular Metabolic Process Cell Communication Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Hypoxia Cellular Macromolecule Catabolic Process Transcription, DNA-templated Cellular Protein Metabolic Process Cell Cycle Arrest Catabolic Process Regulation Of Cell Cycle RNA Biosynthetic Process Intracellular Signal Transduction	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Notch Signaling Pathway Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Negative Regulation Of Signaling Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Monoubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Viral Life Cycle Regulation Of ERBB Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Catabolic Process Cellular Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction
Tagcloud ?		attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1	bioinformatics cd53 coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Difference) ?		attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1	bioinformatics cd53 coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Intersection) ?