HUWE1 and CCL1

Number of citations of the paper that reports this interaction (PMID 15989956)
126

Data Source:
HPRD (in vitro)

		HUWE1	CCL1
Gene Name		HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	chemokine (C-C motif) ligand 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Vesicular Exosome	Extracellular Space
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Poly(A) RNA Binding	Chemokine Activity
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Histone Ubiquitination Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Signal Transduction Viral Process Cell Chemotaxis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 22412388)
Protein-Protein Interactions		20 interactors: ABL1 CALM1 CCL1 CDKN2A HDAC2 LAPTM5 MCL1 MYC PIAS2 POLB RNF11 SMAD2 SMAD9 TP53 UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4	2 interactors: CCR8 HUWE1
Entrez ID		10075	6346
HPRD ID		06608	01654
Ensembl ID		ENSG00000086758	ENSG00000108702
Uniprot IDs		Q7Z6Z7	P22362
PDB IDs		2EKK 3G1N 3H1D	1EL0
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Stress Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Ubiquitination Signal Transduction Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Signaling Cellular Response To Oxygen Levels Negative Regulation Of Cellular Metabolic Process Cell Communication Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Hypoxia Cellular Macromolecule Catabolic Process Transcription, DNA-templated Cellular Protein Metabolic Process Cell Cycle Arrest Catabolic Process Regulation Of Cell Cycle RNA Biosynthetic Process Intracellular Signal Transduction
Tagcloud ?		attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1	aacr adequate aurka aurora bioavailability ccl5 cleared coadministered combining cxcl9 depolarization ends escape harboring leukocytes leverages lifespan mdm2 offers prominent proof rationale rejection reliant res senescence senescent sound therapeutics
Tagcloud (Difference) ?		attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1	aacr adequate aurka aurora bioavailability ccl5 cleared coadministered combining cxcl9 depolarization ends escape harboring leukocytes leverages lifespan mdm2 offers prominent proof rationale rejection reliant res senescence senescent sound therapeutics
Tagcloud (Intersection) ?