HUWE1 and UBE2G1

Number of citations of the paper that reports this interaction (PMID 22016339)
8

Data Source:
BioGRID (pull down)

		HUWE1	UBE2G1
Gene Name		HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2G 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Vesicular Exosome	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Poly(A) RNA Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Histone Ubiquitination Cell Differentiation Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ABL1 CALM1 CCL1 CDKN2A HDAC2 LAPTM5 MCL1 MYC PIAS2 POLB RNF11 SMAD2 SMAD9 TP53 UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4	13 interactors: AMFR APP CBL DIO2 HUWE1 ITCH MARCH6 PARK2 RBCK1 RBX1 UBA1 UBE2E1 UBE3A
Entrez ID		10075	7326
HPRD ID		06608	03340
Ensembl ID		ENSG00000086758	ENSG00000132388
Uniprot IDs		Q7Z6Z7	P62253
PDB IDs		2EKK 3G1N 3H1D	2AWF
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Stress Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Ubiquitination Signal Transduction Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Signaling Cellular Response To Oxygen Levels Negative Regulation Of Cellular Metabolic Process Cell Communication Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Hypoxia Cellular Macromolecule Catabolic Process Transcription, DNA-templated Cellular Protein Metabolic Process Cell Cycle Arrest Catabolic Process Regulation Of Cell Cycle RNA Biosynthetic Process Intracellular Signal Transduction	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Catabolic Process Protein Monoubiquitination Protein Metabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K29-linked Ubiquitination Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Protein Catabolic Process Notch Signaling Pathway Negative Regulation Of JNK Cascade Protein K63-linked Ubiquitination Intracellular Receptor Signaling Pathway Viral Process Regulation Of Protein Ubiquitination Negative Regulation Of Stress-activated MAPK Cascade Histone Ubiquitination Positive Regulation Of Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Autoubiquitination Regulation Of Signal Transduction Response To Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Learning Or Memory Cognition Positive Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Sperm Entry Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Signaling
Tagcloud ?		attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1
Tagcloud (Difference) ?		attractive bicyclic biol catalyze chem cys displacement druggable e2 e3 freund heclin hect heinis hek293 huge kills ligase ligases makes mule nat phage proven rutherford smurf2 thioesters winter wwp1
Tagcloud (Intersection) ?