ROCK1 and GFAP

Number of citations of the paper that reports this interaction (PMID 9099667)
23

Data Source:
HPRD (in vitro, in vivo)

		ROCK1	GFAP
Gene Name		Rho-associated, coiled-coil containing protein kinase 1	glial fibrillary acidic protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb	Cytoplasm Cytosol Intermediate Filament Membrane Cell Body Astrocyte End-foot
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding	Integrin Binding Structural Constituent Of Cytoskeleton Kinase Binding
	Biological Process	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Response To Wounding Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Neuron Projection Development Astrocyte Development Extracellular Matrix Organization Neuron Projection Regeneration Intermediate Filament Organization Regulation Of Neurotransmitter Uptake Bergmann Glial Cell Differentiation Long-term Synaptic Potentiation
Pathways		Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Nuclear signaling by ERBB4 Signaling by ERBB4
Drugs		HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM	46 interactors: AES APP AURKB BIRC2 C6orf165 CAMK2A CDK1 CEP76 CRYAB FAM50B GOLGA2 GRAP2 HGS IKBKG KIAA0408 KRT13 KRT15 LGALS14 LMO2 MEN1 MOS MYO15B NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SRC STAT1 TRIM27 TUBGCP4 VIM ZC2HC1C
Entrez ID		6093	2670
HPRD ID		03414	00675
Ensembl ID			ENSG00000131095
Uniprot IDs		Q13464	A7REI1 P14136
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly	Apoptotic Process Regulation Of Protein Binding Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Response To Abiotic Stimulus Immune Response Regulation Of Cell Death Regulation Of Binding Immune System Process Innate Immune Response Regulation Of Cellular Component Organization Cellular Response To Stimulus Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Kinase Activity Protein Autophosphorylation Negative Regulation Of Cellular Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Immune System Process Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Defense Response Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Signaling Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cell Communication Mitotic Nuclear Envelope Disassembly Response To Hypoxia Histone Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Nuclear Envelope Disassembly
Tagcloud ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	astrocyte astroglia bioactivation catechols dense diaminobenzidine effete elemental faint fourfold gliosomes heterogeneously histochemical inclusions laden microanalytical microprobe minority nigra nigral parkinsonism peaks peroxidase predisposing senescent sequestration subcortical substantia ultrastructural
Tagcloud (Difference) ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	astrocyte astroglia bioactivation catechols dense diaminobenzidine effete elemental faint fourfold gliosomes heterogeneously histochemical inclusions laden microanalytical microprobe minority nigra nigral parkinsonism peaks peroxidase predisposing senescent sequestration subcortical substantia ultrastructural
Tagcloud (Intersection) ?