GFAP and CAMK2A

Number of citations of the paper that reports this interaction (PMID 9099667)
23

Data Source:
HPRD (in vitro, in vivo)

		GFAP	CAMK2A
Gene Name		glial fibrillary acidic protein	calcium/calmodulin-dependent protein kinase II alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Membrane Cell Body Astrocyte End-foot	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane
	Molecular Function	Integrin Binding Structural Constituent Of Cytoskeleton Kinase Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	Response To Wounding Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Neuron Projection Development Astrocyte Development Extracellular Matrix Organization Neuron Projection Regeneration Intermediate Filament Organization Regulation Of Neurotransmitter Uptake Bergmann Glial Cell Differentiation Long-term Synaptic Potentiation	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Nuclear signaling by ERBB4 Signaling by ERBB4	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		46 interactors: AES APP AURKB BIRC2 C6orf165 CAMK2A CDK1 CEP76 CRYAB FAM50B GOLGA2 GRAP2 HGS IKBKG KIAA0408 KRT13 KRT15 LGALS14 LMO2 MEN1 MOS MYO15B NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SRC STAT1 TRIM27 TUBGCP4 VIM ZC2HC1C	40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		2670	815
HPRD ID		00675	06532
Ensembl ID		ENSG00000131095	ENSG00000070808
Uniprot IDs		A7REI1 P14136	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs			2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Protein Binding Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Response To Abiotic Stimulus Immune Response Regulation Of Cell Death Regulation Of Binding Immune System Process Innate Immune Response Regulation Of Cellular Component Organization Cellular Response To Stimulus Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Kinase Activity Protein Autophosphorylation Negative Regulation Of Cellular Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Immune System Process Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Defense Response Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Signaling Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cell Communication Mitotic Nuclear Envelope Disassembly Response To Hypoxia Histone Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Nuclear Envelope Disassembly	Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential
Tagcloud ?		astrocyte astroglia bioactivation catechols dense diaminobenzidine effete elemental faint fourfold gliosomes heterogeneously histochemical inclusions laden microanalytical microprobe minority nigra nigral parkinsonism peaks peroxidase predisposing senescent sequestration subcortical substantia ultrastructural	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?		astrocyte astroglia bioactivation catechols dense diaminobenzidine effete elemental faint fourfold gliosomes heterogeneously histochemical inclusions laden microanalytical microprobe minority nigra nigral parkinsonism peaks peroxidase predisposing senescent sequestration subcortical substantia ultrastructural	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Intersection) ?