GFAP and HGS

Number of citations of the paper that reports this interaction (PMID 19019082)
2

Data Source:
BioGRID (pull down)

		GFAP	HGS
Gene Name		glial fibrillary acidic protein	hepatocyte growth factor-regulated tyrosine kinase substrate
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Membrane Cell Body Astrocyte End-foot	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Structural Constituent Of Cytoskeleton Kinase Binding	Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Response To Wounding Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Neuron Projection Development Astrocyte Development Extracellular Matrix Organization Neuron Projection Regeneration Intermediate Filament Organization Regulation Of Neurotransmitter Uptake Bergmann Glial Cell Differentiation Long-term Synaptic Potentiation	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways		Nuclear signaling by ERBB4 Signaling by ERBB4	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Eye color traits ( 20463881)
Protein-Protein Interactions		46 interactors: AES APP AURKB BIRC2 C6orf165 CAMK2A CDK1 CEP76 CRYAB FAM50B GOLGA2 GRAP2 HGS IKBKG KIAA0408 KRT13 KRT15 LGALS14 LMO2 MEN1 MOS MYO15B NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SRC STAT1 TRIM27 TUBGCP4 VIM ZC2HC1C	138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302
Entrez ID		2670	9146
HPRD ID		00675	05085
Ensembl ID		ENSG00000131095	ENSG00000185359
Uniprot IDs		A7REI1 P14136	O14964
PDB IDs			2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Protein Binding Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Response To Abiotic Stimulus Immune Response Regulation Of Cell Death Regulation Of Binding Immune System Process Innate Immune Response Regulation Of Cellular Component Organization Cellular Response To Stimulus Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Kinase Activity Protein Autophosphorylation Negative Regulation Of Cellular Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Immune System Process Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Defense Response Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Signaling Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cell Communication Mitotic Nuclear Envelope Disassembly Response To Hypoxia Histone Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Nuclear Envelope Disassembly	Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance
Tagcloud ?		astrocyte astroglia bioactivation catechols dense diaminobenzidine effete elemental faint fourfold gliosomes heterogeneously histochemical inclusions laden microanalytical microprobe minority nigra nigral parkinsonism peaks peroxidase predisposing senescent sequestration subcortical substantia ultrastructural	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		astrocyte astroglia bioactivation catechols dense diaminobenzidine effete elemental faint fourfold gliosomes heterogeneously histochemical inclusions laden microanalytical microprobe minority nigra nigral parkinsonism peaks peroxidase predisposing senescent sequestration subcortical substantia ultrastructural	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?