ROCK1 and POLR3C

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ROCK1	POLR3C
Gene Name		Rho-associated, coiled-coil containing protein kinase 1	polymerase (RNA) III (DNA directed) polypeptide C (62kD)
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb	Nucleus Nucleoplasm DNA-directed RNA Polymerase III Complex Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding	RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity
	Biological Process	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Regulation Of Transcription From RNA Polymerase III Promoter Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System
Drugs		HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM	8 interactors: APP CEP63 GTF3C4 PNMA5 ROCK1 ROPN1 TNR TRIM27
Entrez ID		6093	10623
HPRD ID		03414	17880
Ensembl ID			ENSG00000186141
Uniprot IDs		Q13464	Q9BUI4
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S	2XUB 2XV4
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly	Axon Guidance Neuromuscular Process Controlling Balance Associative Learning Negative Regulation Of Axon Extension Involved In Regeneration Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Neuromuscular Process Neuron Projection Morphogenesis Learning Collateral Sprouting In Absence Of Injury Cell Morphogenesis Involved In Differentiation Synapse Organization Cellular Component Assembly Neuron Projection Development Negative Regulation Of Neuron Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Membrane To Membrane Docking Cell Projection Morphogenesis Cell Part Morphogenesis 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Apical Constriction Axon Choice Point Recognition TRNA Transcription Locomotory Behavior Neuron Development Negative Regulation Of Axon Regeneration Positive Regulation Of Transmission Of Nerve Impulse Interferon-gamma Secretion Learning Or Memory Neuron Remodeling Cell Morphogenesis Bleb Assembly Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Cognition Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Regulation Of Transmission Of Nerve Impulse Centriole Replication Locomotory Exploration Behavior Positive Regulation Of Cellular Component Biogenesis
Tagcloud ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Difference) ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Intersection) ?