ROCK1 and CASP7

Number of citations of the paper that reports this interaction (PMID 18723680)
71

Data Source:
BioGRID (enzymatic study)

		ROCK1	CASP7
Gene Name		Rho-associated, coiled-coil containing protein kinase 1	caspase 7, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins Apoptotic factor-mediated response SMAC binds to IAPs Apoptotic execution phase Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Intrinsic Pathway for Apoptosis
Drugs		HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE	Fica
Diseases
GWAS			Vitiligo ( 22561518)
Protein-Protein Interactions		32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM	60 interactors: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAPT MAX MEF2A MEF2D NEDD4 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP
Entrez ID		6093	840
HPRD ID		03414	03457
Ensembl ID			ENSG00000165806
Uniprot IDs		Q13464	B4DWA2 P55210
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S	1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Response To Stimulus Regulation Of Cellular Component Organization Cell Communication Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Signaling Myeloid Cell Differentiation System Development Regulation Of Metabolic Process Cellular Response To Organic Substance Viral Process Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Peptidase Activity Anatomical Structure Development Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Multicellular Organismal Development Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
Tagcloud (Difference) ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
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