ROCK1 and DES

Number of citations of the paper that reports this interaction (PMID 10574968)
13

Data Source:
HPRD (in vivo, in vitro)

		ROCK1	DES
Gene Name		Rho-associated, coiled-coil containing protein kinase 1	desmin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb	Cytosol Intermediate Filament Fascia Adherens Z Disc Neuromuscular Junction Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding
Pathways		Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Striated Muscle Contraction
Drugs		HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM	23 interactors: AURKB BRCA1 CAPN1 CRYAB DSP EHHADH ITSN1 MAPKAPK2 NEB PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I
Entrez ID		6093	1674
HPRD ID		03414	00514
Ensembl ID			ENSG00000175084
Uniprot IDs		Q13464	P17661 Q53SB5
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly	Regulation Of Cytoskeleton Organization Intermediate Filament-based Process Apoptotic Process Programmed Cell Death Cell Death Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Developmental Process Response To Abiotic Stimulus Multicellular Organismal Development Muscle Contraction Execution Phase Of Apoptosis Anatomical Structure Development Muscle System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cellular Component Organization Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Cell Death System Development Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process G2 DNA Damage Checkpoint Negative Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Cytoskeleton Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Lipid Response To Steroid Hormone Actin-mediated Cell Contraction Intracellular Signal Transduction Cellular Protein Modification Process Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Histone H4-K20 Methylation Metanephric Distal Tubule Morphogenesis Positive Regulation Of Histone H4-K16 Acetylation Primary Spermatocyte Growth Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Programmed Cell Death Cell Cycle Checkpoint Chromosome Segregation Axonogenesis Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axon Development Proteasomal Protein Catabolic Process
Tagcloud ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Difference) ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Intersection) ?