PREP and KNG1

Number of citations of the paper that reports this interaction (PMID 12173)
9

Data Source:
HPRD (in vitro)

		PREP	KNG1
Gene Name		prolyl endopeptidase	kininogen 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Serine-type Exopeptidase Activity	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	Proteolysis	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		6 interactors: AGT BRCA1 KNG1 NTS OXT TAC1	28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN
Entrez ID		5550	3827
HPRD ID		02673	01970
Ensembl ID		ENSG00000085377
Uniprot IDs		B2RAH7 P48147	P01042
PDB IDs		3DDU	2WOK 4ASQ 4ASR 4ECB 4ECC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Renal Sodium Excretion Regulation Of Renal Sodium Excretion Regulation Of Excretion Blood Circulation Regulation Of Ion Homeostasis Positive Regulation Of Secretion Regulation Of Blood Vessel Size Regulation Of Tube Size Drinking Behavior Cellular Metal Ion Homeostasis Renal System Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Digestive System Process Cellular Chemical Homeostasis Regulation Of Norepinephrine Secretion Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Insemination Regulation Of Secretion Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Cellular Homeostasis Copulation Positive Regulation Of Transport Chemical Homeostasis Regulation Of Fatty Acid Biosynthetic Process Vasodilation Response To Salt Stress Cellular Calcium Ion Homeostasis Positive Regulation Of Blood Pressure Calcium Ion Homeostasis Regulation Of Synaptic Transmission Response To Abiotic Stimulus Mating Response To Activity Regulation Of Neurological System Process Positive Regulation Of Lipid Transport Smooth Muscle Contraction Regulation Of Heart Rate Homeostatic Process Positive Regulation Of Epithelial Cell Migration Regulation Of Fatty Acid Metabolic Process Response To Osmotic Stress Regulation Of Lipid Transport Response To Ammonium Ion Positive Regulation Of Inflammatory Response Feeding Behavior Uterine Smooth Muscle Contraction	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		abdominal airborne alcohol antisepsis antiseptic antiseptics bathing chg chlorhexidine clipping cloths droplet dual ebola flammable gluconate hair impregnated perineal ppe precautions preoperative preparation preps removal respirator vaginal washing words	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Difference) ?		abdominal airborne alcohol antisepsis antiseptic antiseptics bathing chg chlorhexidine clipping cloths droplet dual ebola flammable gluconate hair impregnated perineal ppe precautions preoperative preparation preps removal respirator vaginal washing words	ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Intersection) ?