KNG1 and RXFP4

Number of citations of the paper that reports this interaction (PMID 14530218)
6

Data Source:
HPRD (in vivo)

		KNG1	RXFP4
Gene Name		kininogen 1	relaxin/insulin-like family peptide receptor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding	Angiotensin Type II Receptor Activity Protein Binding
	Biological Process	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis	Angiotensin-activated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	2 interactors: KNG1 RLN3
Entrez ID		3827	339403
HPRD ID		01970	16421
Ensembl ID			ENSG00000173080
Uniprot IDs		P01042	Q8TDU9
PDB IDs		2WOK 4ASQ 4ASR 4ECB 4ECC
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process	Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Urine Volume Blood Coagulation, Intrinsic Pathway Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Smooth Muscle Contraction Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Renal System Process Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Protein Activation Cascade Cytosolic Calcium Ion Homeostasis Platelet Activation Negative Regulation Of Cell Adhesion Muscle Contraction Muscle System Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Blood Circulation Positive Regulation Of Secretion Exocytosis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Blood Coagulation Inflammatory Response Hemostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Secretion By Cell Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death
Tagcloud ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	amidated amidation amide arousal behavioural bonds carboxyl chain chains chemically circular cognate connected dichroism disulfide drop feeding modification modulatory neuropeptide orientation primarily relaxin rxfp3 spectroscopy structurally synthesised termini terminus
Tagcloud (Difference) ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	amidated amidation amide arousal behavioural bonds carboxyl chain chains chemically circular cognate connected dichroism disulfide drop feeding modification modulatory neuropeptide orientation primarily relaxin rxfp3 spectroscopy structurally synthesised termini terminus
Tagcloud (Intersection) ?