KNG1 and KLK1

Number of citations of the paper that reports this interaction (PMID 7492318)
6

Data Source:
HPRD (in vitro)

		KNG1	KLK1
Gene Name		kininogen 1	kallikrein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Nucleus Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding	Serine-type Endopeptidase Activity
	Biological Process	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis	Proteolysis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs			Aprotinin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	3 interactors: KNG1 SERPINA4 SERPINA5
Entrez ID		3827	3816
HPRD ID		01970	01003
Ensembl ID			ENSG00000167748
Uniprot IDs		P01042	F8WAM8 P06870
PDB IDs		2WOK 4ASQ 4ASR 4ECB 4ECC	1SPJ
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Regulation Of Catalytic Activity Positive Regulation Of Renal Sodium Excretion Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Urine Volume Blood Coagulation, Intrinsic Pathway Fusion Of Sperm To Egg Plasma Membrane Plasma Membrane Fusion Response To Wounding Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Smooth Muscle Contraction Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Renal System Process Regulation Of Blood Coagulation Membrane Fusion Regulation Of Wound Healing Single Fertilization Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Protein Activation Cascade Fertilization Cytosolic Calcium Ion Homeostasis Platelet Activation
Tagcloud ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying
Tagcloud (Difference) ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying
Tagcloud (Intersection) ?