PREP and TAC1

Number of citations of the paper that reports this interaction (PMID 12603817)
9

Data Source:
HPRD (in vitro)

		PREP	TAC1
Gene Name		prolyl endopeptidase	tachykinin, precursor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Serine-type Exopeptidase Activity	Protein Binding Substance P Receptor Binding
	Biological Process	Proteolysis	Positive Regulation Of Acute Inflammatory Response Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Corticosterone Secretion
Pathways			G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Adverse response to radiation therapy ( 23719583) Response to platinum-based agents ( 22020760)
Protein-Protein Interactions		6 interactors: AGT BRCA1 KNG1 NTS OXT TAC1	12 interactors: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TAC4 TACR1 TACR2 TACR3 TFF2 XRCC6
Entrez ID		5550	6863
HPRD ID		02673	08876
Ensembl ID		ENSG00000085377	ENSG00000006128
Uniprot IDs		B2RAH7 P48147	P20366 Q9Y494
PDB IDs		3DDU	2B19 2KS9 2KSA 2KSB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Renal Sodium Excretion Regulation Of Renal Sodium Excretion Regulation Of Excretion Blood Circulation Regulation Of Ion Homeostasis Positive Regulation Of Secretion Regulation Of Blood Vessel Size Regulation Of Tube Size Drinking Behavior Cellular Metal Ion Homeostasis Renal System Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Digestive System Process Cellular Chemical Homeostasis Regulation Of Norepinephrine Secretion Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Insemination Regulation Of Secretion Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Cellular Homeostasis Copulation Positive Regulation Of Transport Chemical Homeostasis Regulation Of Fatty Acid Biosynthetic Process Vasodilation Response To Salt Stress Cellular Calcium Ion Homeostasis Positive Regulation Of Blood Pressure Calcium Ion Homeostasis Regulation Of Synaptic Transmission Response To Abiotic Stimulus Mating Response To Activity Regulation Of Neurological System Process Positive Regulation Of Lipid Transport Smooth Muscle Contraction Regulation Of Heart Rate Homeostatic Process Positive Regulation Of Epithelial Cell Migration Regulation Of Fatty Acid Metabolic Process Response To Osmotic Stress Regulation Of Lipid Transport Response To Ammonium Ion Positive Regulation Of Inflammatory Response Feeding Behavior Uterine Smooth Muscle Contraction	Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Regulation Of Smooth Muscle Contraction Operant Conditioning Regulation Of Saliva Secretion Hyperosmotic Salinity Response Neuropeptide Signaling Pathway Blood Circulation Positive Regulation Of Digestive System Process Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Hyperosmotic Response Regulation Of Blood Pressure Regulation Of Vascular Permeability Response To Salt Stress Positive Regulation Of Blood Pressure Response To Morphine Regulation Of Secretion Response To Electrical Stimulus Excretion Smooth Muscle Contraction Positive Regulation Of Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Acute Inflammatory Response Response To Osmotic Stress Response To Ammonium Ion Positive Regulation Of Synaptic Transmission Cellular Hyperosmotic Salinity Response Smooth Muscle Contraction Involved In Micturition Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Response To Abiotic Stimulus Digestion Response To Estradiol G-protein Coupled Receptor Signaling Pathway Regulation Of Acetylcholine Secretion, Neurotransmission Calcium-independent Cell-matrix Adhesion Learning Positive Regulation Of Synaptic Transmission, Cholinergic Response To Alkaloid Synaptic Transmission Prolactin Secretion Cellular Response To X-ray Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Gonadotropin Secretion Micturition Response To Ozone
Tagcloud ?		abdominal airborne alcohol antisepsis antiseptic antiseptics bathing chg chlorhexidine clipping cloths droplet dual ebola flammable gluconate hair impregnated perineal ppe precautions preoperative preparation preps removal respirator vaginal washing words	1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd
Tagcloud (Difference) ?		abdominal airborne alcohol antisepsis antiseptic antiseptics bathing chg chlorhexidine clipping cloths droplet dual ebola flammable gluconate hair impregnated perineal ppe precautions preoperative preparation preps removal respirator vaginal washing words	1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd
Tagcloud (Intersection) ?