KNG1 and KRT1

Number of citations of the paper that reports this interaction (PMID 10066772)
6

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KNG1	KRT1
Gene Name		kininogen 1	keratin 1, type II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Nucleus Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Keratin Filament Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding	Receptor Activity Structural Molecule Activity Protein Binding Carbohydrate Binding
	Biological Process	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Fibrinolysis Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Establishment Of Skin Barrier
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	15 interactors: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT5 LOR MBL2 PI3 PRKCE YWHAQ
Entrez ID		3827	3848
HPRD ID		01970	00763
Ensembl ID			ENSG00000167768
Uniprot IDs		P01042	P04264
PDB IDs		2WOK 4ASQ 4ASR 4ECB 4ECC
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process	Peptide Cross-linking Keratinocyte Differentiation Epidermis Development Epidermal Cell Differentiation Skin Development Keratinization Epithelial Cell Differentiation Epithelium Development Blood Coagulation, Intrinsic Pathway Regulation Of Wound Healing Regulation Of Protein Processing Protein Activation Cascade Cytosolic Calcium Ion Homeostasis Tissue Development Positive Regulation Of Wound Healing Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Peptidase Activity Negative Regulation Of Coagulation Positive Regulation Of Cellular Glucuronidation Response To Wounding Cellular Calcium Ion Homeostasis Negative Regulation Of Wound Healing Calcium Ion Homeostasis Positive Regulation Of Transport Anatomical Structure Development Acute Inflammatory Response Organ Development Negative Regulation Of Proteolysis Ventricular Compact Myocardium Morphogenesis Factor XII Activation TRAM-dependent Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Blood Coagulation Negative Regulation Of Hydrolase Activity Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Blood Coagulation Inflammatory Response Developmental Process Hemostasis Protein Metabolic Process Cellular Cation Homeostasis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Localization To Adherens Junction Positive Regulation Of Fibrinolysis Cellular Ion Homeostasis Response To Stress
Tagcloud ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously
Tagcloud (Difference) ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously
Tagcloud (Intersection) ?