SERPINF2 and DEFA1

Number of citations of the paper that reports this interaction (PMID 7873202)
18

Data Source:
HPRD (in vitro)

		SERPINF2	DEFA1
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	defensin, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Azurophil Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Innate Immune Response In Mucosa Chemotaxis Immune Response Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Innate Immune Response Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation	Alpha-defensins Defensins Innate Immune System
Drugs		Ocriplasmin
Diseases
GWAS		Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	5 interactors: C1QB DEFA3 GSK3B PFDN1 SERPINF2
Entrez ID		5345	1667
HPRD ID		02029	00499
Ensembl ID		ENSG00000167711	ENSG00000206047
Uniprot IDs		P08697	P59665
PDB IDs			2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process	Defense Response Immune System Process Innate Immune Response Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Blood Vessel Size By Renin-angiotensin Humoral Immune Response Cellular Response To Interleukin-3 Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Telencephalon Development Immune Response Negative Regulation Of Plasminogen Activation Protein Localization To Microtubule Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Fibrinolysis Response To Stress ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Adhesion Regulation Of Fibrinolysis Positive Regulation Of Organelle Organization Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Forebrain Development Innate Immune Response In Mucosa Intracellular Estrogen Receptor Signaling Pathway System Development Regulation Of DNA Methylation Positive Regulation Of Transforming Growth Factor Beta Production Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Killing Of Cells Of Other Organism Positive Regulation Of Collagen Biosynthetic Process Antibacterial Humoral Response Positive Regulation Of Collagen Metabolic Process Defense Response To Fungus
Tagcloud ?			a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized
Tagcloud (Difference) ?			a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized
Tagcloud (Intersection) ?