DEFA1 and C1QB

Number of citations of the paper that reports this interaction (PMID 9444979)
10

Data Source:
HPRD (in vitro)

		DEFA1	C1QB
Gene Name		defensin, alpha 1	complement component 1, q subcomponent, B chain
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Azurophil Granule Lumen Extracellular Vesicular Exosome	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function		Protein Binding Protein Homodimerization Activity
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Immune Response Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Innate Immune Response Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus	Complement Activation Complement Activation, Classical Pathway Innate Immune Response Inner Ear Development
Pathways		Alpha-defensins Defensins Innate Immune System	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: C1QB DEFA3 GSK3B PFDN1 SERPINF2	10 interactors: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA
Entrez ID		1667	713
HPRD ID		00499	00394
Ensembl ID		ENSG00000206047	ENSG00000173369
Uniprot IDs		P59665	P02746
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0	1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Defense Response Immune System Process Innate Immune Response Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Blood Vessel Size By Renin-angiotensin Humoral Immune Response Cellular Response To Interleukin-3 Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Telencephalon Development Immune Response Negative Regulation Of Plasminogen Activation Protein Localization To Microtubule Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Fibrinolysis Response To Stress ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Adhesion Regulation Of Fibrinolysis Positive Regulation Of Organelle Organization Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Forebrain Development Innate Immune Response In Mucosa Intracellular Estrogen Receptor Signaling Pathway System Development Regulation Of DNA Methylation Positive Regulation Of Transforming Growth Factor Beta Production Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Killing Of Cells Of Other Organism Positive Regulation Of Collagen Biosynthetic Process Antibacterial Humoral Response Positive Regulation Of Collagen Metabolic Process Defense Response To Fungus	Defense Response Immune Response Innate Immune Response Response To Fungus Humoral Immune Response Positive Regulation Of Immune Response Immune System Process Response To Stress Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Response To Stimulus Protein Activation Cascade Positive Regulation Of Focal Adhesion Assembly Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Positive Regulation Of Adherens Junction Organization Defense Response To Fungus Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Other Organism Leukocyte Mediated Immunity Adaptive Immune Response Response To Biotic Stimulus Regulation Of Focal Adhesion Assembly Positive Regulation Of Cell-matrix Adhesion Regulation Of Cell Junction Assembly ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Acetaldehyde Metabolic Process Cellular Response To Tumor Necrosis Factor ERBB2 Signaling Pathway Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Schwann Cell Differentiation Heme Export Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Exo-alpha-sialidase Activity Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Schwann Cell Differentiation Negative Regulation Of Lamellipodium Assembly Response To Tumor Necrosis Factor Negative Regulation Of Endothelial Cell Chemotaxis Response To Cobalamin Defense Response To Virus Regulation Of Locomotion
Tagcloud ?		a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Difference) ?		a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Intersection) ?