SERPINF2 and CTRB1

Number of citations of the paper that reports this interaction (PMID 2456616)
10

Data Source:
HPRD (in vitro)

		SERPINF2	CTRB1
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	chymotrypsinogen B1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Serine-type Endopeptidase Activity
	Biological Process	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Proteolysis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Digestion Cobalamin Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Small Molecule Metabolic Process
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs		Ocriplasmin
Diseases
GWAS		Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	4 interactors: LYPD3 SERPINA1 SERPINA3 SERPINF2
Entrez ID		5345	1504
HPRD ID		02029	00345
Ensembl ID		ENSG00000167711	ENSG00000168925
Uniprot IDs		P08697
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process	Acute-phase Response Acute Inflammatory Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Inflammatory Response Platelet Degranulation Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Response To Methanol Negative Regulation Of Protein Metabolic Process Response To Triglyceride Platelet Activation Response To Chromate Regulation Of Blood Vessel Size By Renin-angiotensin Defense Response Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Exocytosis Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Blood Coagulation Hemostasis Regulation Of Fibrinolysis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Maintenance Of Gastrointestinal Epithelium Secretion By Cell Regulation Of Protein Metabolic Process Epithelial Structure Maintenance Regulation Of Body Fluid Levels Positive Regulation Of Transforming Growth Factor Beta Production Wound Healing Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Catalytic Activity Secretion Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Response To Lead Ion Cell Activation Fibrinolysis Response To Wounding Positive Regulation Of Blood Coagulation
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