SERPINF2 and SERPINB12

Number of citations of the paper that reports this interaction (PMID 11604408)
6

Data Source:
HPRD (in vitro)

		SERPINF2	SERPINB12
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	serpin peptidase inhibitor, clade B (ovalbumin), member 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Serine-type Endopeptidase Inhibitor Activity Enzyme Binding
	Biological Process	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Catabolic Process
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs		Ocriplasmin
Diseases
GWAS		Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	2 interactors: SERPINF2 UCHL5
Entrez ID		5345	89777
HPRD ID		02029	11548
Ensembl ID		ENSG00000167711	ENSG00000166634
Uniprot IDs		P08697	Q3SYB4 Q96P63
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Blood Vessel Size By Renin-angiotensin Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Proteolysis Regulation Of Fibrinolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Production Forebrain Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Lateral Ventricle Development Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Fibrinolysis Positive Regulation Of Blood Coagulation Regulation Of Collagen Metabolic Process Acute-phase Response Positive Regulation Of Coagulation Brain Morphogenesis Positive Regulation Of Stress Fiber Assembly Ventricular System Development Positive Regulation Of Wound Healing Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Blood Coagulation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Coagulation Collagen Fibril Organization Regulation Of Stress Fiber Assembly Negative Regulation Of Wound Healing Platelet Degranulation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Acute Inflammatory Response Regulation Of Cellular Protein Metabolic Process Midbrain Development Negative Regulation Of Cellular Metabolic Process Regulation Of Systemic Arterial Blood Pressure Renal System Process Regulation Of Blood Coagulation
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