DEFA1 and DEFA3

Number of citations of the paper that reports this interaction (PMID 2997278)
236

Data Source:
HPRD (in vitro)

		DEFA1	DEFA3
Gene Name		defensin, alpha 1	defensin, alpha 3, neutrophil-specific
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Azurophil Granule Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Vesicular Exosome
	Molecular Function		Molecular_function
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Immune Response Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Innate Immune Response Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus	Innate Immune Response In Mucosa Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Innate Immune Response Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus
Pathways		Alpha-defensins Defensins Innate Immune System	Alpha-defensins Defensins Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: C1QB DEFA3 GSK3B PFDN1 SERPINF2	1 interactors: DEFA1
Entrez ID		1667	1668
HPRD ID		00499	05159
Ensembl ID		ENSG00000206047	ENSG00000239839
Uniprot IDs		P59665	P59666 Q6EZE9
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0	1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5
Enriched GO Terms of Interacting Partners?		Defense Response Immune System Process Innate Immune Response Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Blood Vessel Size By Renin-angiotensin Humoral Immune Response Cellular Response To Interleukin-3 Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Telencephalon Development Immune Response Negative Regulation Of Plasminogen Activation Protein Localization To Microtubule Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Fibrinolysis Response To Stress ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Adhesion Regulation Of Fibrinolysis Positive Regulation Of Organelle Organization Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Forebrain Development Innate Immune Response In Mucosa Intracellular Estrogen Receptor Signaling Pathway System Development Regulation Of DNA Methylation Positive Regulation Of Transforming Growth Factor Beta Production Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Killing Of Cells Of Other Organism Positive Regulation Of Collagen Biosynthetic Process Antibacterial Humoral Response Positive Regulation Of Collagen Metabolic Process Defense Response To Fungus	Innate Immune Response In Mucosa Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Antibacterial Humoral Response Defense Response To Fungus Antimicrobial Humoral Response Mucosal Immune Response Response To Fungus Defense Response To Gram-positive Bacterium Intracellular Steroid Hormone Receptor Signaling Pathway Defense Response To Virus Defense Response To Bacterium Intracellular Receptor Signaling Pathway Humoral Immune Response Response To Virus Response To Bacterium Chemotaxis
Tagcloud ?		a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized
Tagcloud (Difference) ?		a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized
Tagcloud (Intersection) ?